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MAB318-AF555 Anti-Tyrosine Hydroxylase Antibody, clone LNC1, Alexa Fluor® 555 Conjugate

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Neuroscience Research Sub-Category: Neuronal & Glial Markers Gene Symbol: TH, TYH, DYT14, DYT5b UniProt Number: P07101
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MAB318-AF555
100 µL  
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Key Specifications Table

Species ReactivityKey ApplicationsHostFormatAntibody Type
Zebrafish, Ch, Fg, H, M, R, Vo, MkICCMAlexaFluor®555Monoclonal Antibody
Description
Catalogue NumberMAB318-AF555
DescriptionAnti-Tyrosine Hydroxylase Antibody, clone LNC1, Alexa Fluor® 555 Conjugate
Alternate Names
  • Tyrosine 3-monooxygenase
  • Dystonia 14
  • Tyrosine 3-hydroxylase
  • TH
Background InformationTyrosine 3-monooxygenase (EC 1.14.16.2; UniProt P07101; also known as Dystonia 14, TH, Tyrosine 3-hydroxylase) is encoded by the TH (also known as DYT14, DYT5b, TYH) gene (Gene ID 7054) in human. Tyrosine hydroxylase plays an important role in the physiology of adrenergic neurons. It is the first and rate-limiting enzyme involved in the biosynthesis of dopamine and norepinephrine from tyrosine. TH is, therefore, a useful marker for dopaminergic and noradrenergic neurons. TH enzymatic activity requires ferrous ions as cofactor and is believed to be regulated by phosphorylation. Six isoforms of human TH exist as a result of alternative splicing (UniProt P07101-1 through P07101-6).
References
Product Information
FormatAlexaFluor®555
PresentationPurified mouse monoclonal IgG1κ antibody conjugate in PBS with 15 mg/mL BSA and 0.1 % sodium azide.
Quality LevelMQ100
Applications
Key Applications
  • Immunocytochemistry
Application NotesThe unconjugated antibody (Cat. No. MAB318) is shown to be suitable also for Western blotting, immunohistochemistry, and immunoprecipitation applications.
Biological Information
ImmunogenTyrosine Hydroxylase purified from PC12 cells.
EpitopeOn the outside of the regulatory N-terminus of tyrosine hydroxylase.
CloneLNC1
ConcentrationPlease refer to lot specific datasheet.
HostMouse
SpecificityRecognizes an epitope on the outside of the regulatory N-terminus. The unconjugated antibody (Cat. No. MAB318) recognizes a protein of approximately 59-61 kDa by Western blotting. The unconjugated antibody does not react with the following by Western blotting: dopamine-beta-hydroxylase, phenylalanine hydroxylase, trytophan hydroxylase, dehydropteridine reductase, sepiapterin reductase or phenethanolamine-N-methyl transferase (PNMT).
IsotypeIgG1κ
Species Reactivity
  • Zebrafish
  • Chicken
  • Frog
  • Human
  • Mouse
  • Rat
  • Vole
  • Monkey
Antibody TypeMonoclonal Antibody
Entrez Gene Number
Gene Symbol
  • TH
  • TYH
  • DYT14
  • DYT5b
Purification MethodProtein A Purfied
UniProt Number
Molecular Weight~59-63 kDa observed.
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality AssuranceEvaluated by Immunocytochemistry in rat cortical neurons.

Immunocytochemistry Analysis: A 1:100 dilution of this antibody detected Tyrosine Hydroxylase in rat cortical neurons.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
Packaging Information
Material Size100 µL
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalog Number GTIN
MAB318-AF555 04055977311969

Documentation

Anti-Tyrosine Hydroxylase Antibody, clone LNC1, Alexa Fluor® 555 Conjugate SDS

Title

Safety Data Sheet (SDS) 

Anti-Tyrosine Hydroxylase Antibody, clone LNC1, Alexa Fluor® 555 Conjugate Certificates of Analysis

TitleLot Number
Anti- Tyrosine Hydroxylase, clone LNC1, Alexa Fluor® 555 Conjugate - 3886614 3886614
Anti- Tyrosine Hydroxylase, clone LNC1, Alexa Fluor® 555 Conjugate - 4033479 4033479
Anti- Tyrosine Hydroxylase, clone LNC1, Alexa Fluor® 555 Conjugate - 4090083 4090083
Anti- Tyrosine Hydroxylase, clone LNC1, Alexa Fluor® 555 Conjugate - 4204605 4204605
Anti-Tyrosine Hydroxylase, clone LNC1, Alexa Fluor® 555 Conjugate - 3213949 3213949
Anti-Tyrosine Hydroxylase, clone LNC1, Alexa Fluor® 555 Conjugate - 3283657 3283657
Anti-Tyrosine Hydroxylase, clone LNC1, Alexa Fluor® 555 Conjugate - 3460512 3460512
Anti-Tyrosine Hydroxylase, clone LNC1, Alexa Fluor® 555 Conjugate - 3524277 3524277
Anti-Tyrosine Hydroxylase, clone LNC1, Alexa Fluor® 555 Conjugate - 3727569 3727569
Anti-Tyrosine Hydroxylase, clone LNC1, Alexa Fluor® 555 Conjugate - 3754073 3754073
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Brochure

Title
Neuroscience Solutions for productive research

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Categories

Life Science Research > Antibodies and Assays > Primary Antibodies