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06-1334 Anti-phospho-TAB1 (Thr431) Antibody

This Anti-phospho-TAB1 (Thr431) Antibody is validated for use in WB for the detection of phospho-TAB1 (Thr431).

Anti-phospho-TAB1 (Thr431) Antibody MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Inflammation & Immunology Research Sub-Category: Immunoglobulins & Immunology Gene Symbol: TAB1, MAP3K7IP UniProt Number: Q15750
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06-1334
100 µg  
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Key Specifications Table

Species ReactivityKey ApplicationsHostFormatAntibody Type
M, H, R, Eq, OxWBRbAffinity PurifiedPolyclonal Antibody
Description
Catalogue Number06-1334
DescriptionAnti-phospho-TAB1 (Thr431) Antibody
Alternate Names
  • TGF-beta activated kinase 1/MAP3K7 binding protein 1
  • TAK1-binding protein 1
  • transforming growth factor beta-activated kinase-binding protein 1
  • mitogen-activated protein kinase kinase kinase 7 interacting protein 1
  • Mitogen-activated protein kinase kinase kinase 7-interacting protein 1
  • 3'-Tab1
  • TGF-beta-activated kinase 1-binding protein 1
  • TGF-beta-activated kinase 1 and MAP3K7-binding protein 1
Background InformationTAK1 binding protein 1 (TAB1) is thought to activate TAK1 MAPKKK in transforming growth factor-beta (TGF-beta) signaling. TAB1 can also associate with TAK1 to form a unique MAPKKK complex that is thought to activate AP-1 and the NFkappaB signaling pathways. Through conformational changes, TAB1 is also thought to induce p38alpha autophosphorylation. It has been linked to both IL-1alpha and TNFalpha signaling and therefore may also be involved in the inflammatory response. Recent research has found that the TAK1-TAB1 complex may have anti-inflammatory effects by aiding stercurensin in regulating the NFκB-dependent inflammatory pathways.
References
Product Information
FormatAffinity Purified
Control
  • L6 cell lysate
PresentationPurified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Quality LevelMQ100
Applications
ApplicationThis Anti-phospho-TAB1 (Thr431) Antibody is validated for use in WB for the detection of phospho-TAB1 (Thr431).
Key Applications
  • Western Blotting
Biological Information
ImmunogenKLH-conjugated linear peptide corresponding to human TAB1 phosphorylated at Thr431.
EpitopePhosphorylated Thr431
ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
HostRabbit
SpecificityThis antibody recognizes TAB1 phosphorylated at Thr431.
Species Reactivity
  • Mouse
  • Human
  • Rat
  • Horse
  • Ox
Species Reactivity NoteDemonstrated to react with Mouse, Human, and Rat. Predicted to react with Equine and Ox based on 100% sequence homology.
Antibody TypePolyclonal Antibody
Entrez Gene Number
Entrez Gene SummaryThe protein encoded by this gene was identified as a regulator of the MAP kinase kinase kinase MAP3K7/TAK1, which is known to mediate various intracellular signaling pathways, such as those induced by TGF beta, interleukin 1, and WNT-1. This protein interacts and thus activates TAK1 kinase. It has been shown that the C-terminal portion of this protein is sufficient for binding and activation of TAK1, while a portion of the N-terminus acts as a dominant-negative inhibitor of TGF beta, suggesting that this protein may function as a mediator between TGF beta receptors and TAK1. This protein can also interact with and activate the mitogen-activated protein kinase 14 (MAPK14/p38alpha), and thus represents an alternative activation pathway, in addition to the MAPKK pathways, which contributes to the biological responses of MAPK14 to various stimuli. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq].
Gene Symbol
  • TAB1
  • MAP3K7IP
Modifications
  • Phosphorylation
Purification MethodAffinity Purfied
UniProt Number
UniProt SummaryFUNCTION: May be an important signaling intermediate between TGFB receptors and MAP3K7/TAK1. May play an important role in mammalian embryogenesis.

SUBUNIT STRUCTURE: Interacts with XIAP and BIRC7. Interacts with TRAF6 and MAP3K7; during IL-1 signaling. Identified in the TRIKA2 complex composed of MAP3K7, TAB1 and TAB2.

TISSUE SPECIFICTY: Ubiquitous.

PTM: Monoubiquitinated. Deubiquitinated by Y.enterocolitica YopP.

SEQUENCE SIMILARITIES: Contains 1 PP2C-like domain.
Molecular Weight~78 kDa observed. 55 kDa calculated. A higher molecular weight on western blot may be due to glycosylation. An uncharacterized band appears at ~42 and 50 kDa in some lysates.
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality AssuranceEvaluated by Western Blot in L6 cell lysate.

Western Blot Analysis: 1 µg/mL of this antibody detected TAB1 on 10 µg of L6 cell lysate.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
Packaging Information
Material Size100 µg
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalog Number GTIN
06-1334 04053252751622