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169756 Antithrombin III, Human Plasma - CAS 90170-80-2 - Calbiochem

Antithrombin III, Human Plasma, CAS 90170-80-2, is a single-chain glycoprotein that acts as a principal physiological inhibitor of thrombin.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: ATIII, Heparin cofactor, Factor Xa inhibitor

Primary Target: thrombin
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Overview

Replacement Information

Key Specifications Table

CAS #
90170-80-2

Products

Catalog NumberPackaging Qty/Pack
169756-1MG Glass bottle 1 mg
Description
OverviewSingle-chain glycoprotein present in normal serum at about 23 mg/100 ml. Principal physiological inhibitor of thrombin. Present at higher levels in plasma than in serum because it complexes with thrombin during coagulation. Functions by inhibiting proteolytic enzymes involved in blood coagulation and fibrinolysis, including Factor Xa, plasmin, thrombin, and trypsin. Potency is strongly enhanced by heparin.
Catalogue Number169756
Brand Family Calbiochem®
SynonymsATIII, Heparin cofactor, Factor Xa inhibitor
References
ReferencesTsiang, M., et al. 1997. J. Biol. Chem. 272, 12024.
Product Information
CAS number90170-80-2
Unit of DefinitionOne unit is defined as the amount of antithrombin that will inhibit 1.0 unit of human plasma thrombin present in excess. Thrombin activity is measured using 500 µM tosyl-Gly-Pro-Arg-pNA as substrate in 100 mM Tris-HCl at 25°C, pH 8.2
ATP CompetitiveN
FormSolid
FormulationLyophilized from 100 mM sodium citrate buffer, 20 mM Tris-HCl, pH 8.3.
ReversibleN
Quality LevelMQ100
Applications
ApplicationAntithrombin III, Human Plasma, CAS 90170-80-2, is a single-chain glycoprotein that acts as a principal physiological inhibitor of thrombin.
Biological Information
Primary Targetthrombin
Puritysingle band by SDS-PAGE
SourcePrepared from plasma that has been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.
Specific Activity≥5 units/mg protein
Physicochemical Information
Cell permeableN
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 4 months at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalog Number GTIN
169756-1MG 04055977207729

Documentation

Antithrombin III, Human Plasma - CAS 90170-80-2 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

Antithrombin III, Human Plasma - CAS 90170-80-2 - Calbiochem Certificates of Analysis

TitleLot Number
169756

References

Reference overview
Tsiang, M., et al. 1997. J. Biol. Chem. 272, 12024.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision11-April-2008 RFH
SynonymsATIII, Heparin cofactor, Factor Xa inhibitor
DescriptionSingle chain glycoprotein present in normal serum at about 23 mg/100 ml. Principal physiological inhibitor of thrombin. Present at higher levels in plasma than in serum because it complexes with thrombin during coagulation. Functions by inhibiting proteolytic enzymes involved in blood coagulation and fibrinolysis, including Factor Xa, plasmin, thrombin, and trypsin. Potency is strongly enhanced by heparin.
FormSolid
FormulationLyophilized from 100 mM sodium citrate buffer, 20 mM Tris-HCl, pH 8.3.
SourcePrepared from plasma that has been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.
CAS number90170-80-2
Puritysingle band by SDS-PAGE
Specific activity≥5 units/mg protein
Unit definitionOne unit is defined as the amount of antithrombin that will inhibit 1.0 unit of human plasma thrombin present in excess. Thrombin activity is measured using 500 µM tosyl-Gly-Pro-Arg-pNA as substrate in 100 mM Tris-HCl at 25°C, pH 8.2
SolubilityH₂O. Please refer to label for lot-specific volume prior to lyophilization.
Storage -20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 4 months at -20°C.
Toxicity Standard Handling
ReferencesTsiang, M., et al. 1997. J. Biol. Chem. 272, 12024.