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178270 Apamin, Bee Venom - CAS 24345-16-2 - Calbiochem

Polypeptide neurotoxin known to pass through the blood-brain barrier.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: CNCKAPETALCARRCQQH-NH₂

Primary Target: AHP-type Ca2+-activated K+ channel
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Overview

Replacement Information

Key Specifications Table

CAS #Empirical Formula
24345-16-2C₇₉H₁₃₁N₃₁O₂₄S₄

Products

Catalog NumberPackaging Qty/Pack
178270-500UG Plastic ampoule 500 μg
Description
OverviewPolypeptide neurotoxin known to pass through the blood-brain barrier. Blocks the AHP-type Ca2+-activated K+ channel; does not block the TEA and voltage-sensitive Ca2+-activated K+ channel. Reported to induce neurodegeneration of Purkinje cells in rat brain. Known to induce the secretion of prolactin in a dose-dependent manner.
Catalogue Number178270
Brand Family Calbiochem®
SynonymsCNCKAPETALCARRCQQH-NH₂
References
ReferencesMourre, C., et al. 1997. Brain Res. 778, 405.
Silva, E.G., et al. 1994. Br. J. Pharmacol. 113, 1022.
Wang, X., et al. 1994. Brain Res. 662, 83.
Product Information
CAS number24345-16-2
ATP CompetitiveN
FormWhite solid with dark tan cast
Hill FormulaC₇₉H₁₃₁N₃₁O₂₄S₄
Chemical formulaC₇₉H₁₃₁N₃₁O₂₄S₄
Hygroscopic Hygroscopic
ReversibleN
Quality LevelMQ100
Applications
Biological Information
Primary TargetAHP-type Ca2+-activated K+ channel
Purity≥98% by HPLC
Physicochemical Information
Cell permeableN
Peptide SequenceH-Cys¹-Asn-Cys³-Lys-Ala-Pro-Glu-Thr-Ala-Leu-Cys¹¹-Ala-Arg-Arg-Cys¹⁵-Gln-Gln-His-NH₂ (disulfide bonds: 1 → 11; 3 → 15)
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
RTECSCD6899900
Safety Information
R PhraseR: 20/21/22

Harmful by inhalation, in contact with skin and if swallowed.
S PhraseS: 36

Wear suitable protective clothing.
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Harmful
Storage -20°C
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Acetic acid stock solutions are stable for up to 3 days at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalog Number GTIN
178270-500UG 04055977223156

Documentation

Apamin, Bee Venom - CAS 24345-16-2 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

Apamin, Bee Venom - CAS 24345-16-2 - Calbiochem Certificates of Analysis

TitleLot Number
178270

References

Reference overview
Mourre, C., et al. 1997. Brain Res. 778, 405.
Silva, E.G., et al. 1994. Br. J. Pharmacol. 113, 1022.
Wang, X., et al. 1994. Brain Res. 662, 83.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision15-April-2008 RFH
SynonymsCNCKAPETALCARRCQQH-NH₂
DescriptionA polypeptide neurotoxin known to pass through the blood-brain barrier. Blocks the AHP-type Ca2+-activated K+ channel; however, it does not block the TEA and voltage-sensitive Ca2+-activated K+ channel. Known to induce the secretion of prolactin in a dose-dependent manner.
FormWhite solid with dark tan cast
CAS number24345-16-2
RTECSCD6899900
Chemical formulaC₇₉H₁₃₁N₃₁O₂₄S₄
Peptide SequenceH-Cys¹-Asn-Cys³-Lys-Ala-Pro-Glu-Thr-Ala-Leu-Cys¹¹-Ala-Arg-Arg-Cys¹⁵-Gln-Gln-His-NH₂ (disulfide bonds: 1 → 11; 3 → 15)
Purity≥98% by HPLC
Solubility5% Acetic Acid (2 mg/ml)
Storage -20°C
Hygroscopic
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Acetic acid stock solutions are stable for up to 3 days at -20°C.
Toxicity Harmful
Merck USA index14, 725
ReferencesMourre, C., et al. 1997. Brain Res. 778, 405.
Silva, E.G., et al. 1994. Br. J. Pharmacol. 113, 1022.
Wang, X., et al. 1994. Brain Res. 662, 83.