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178497 Apoptosis Activator VII, Apoptozole - CAS 1054543-47-3 - Calbiochem

The Apoptosis Activator VII, Apoptozole, also referenced under CAS 1054543-47-3, modulates Apoptosis. This small molecule/inhibitor is primarily used for Cancer applications.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Hsp70 Inhibitor III, N-(4-Carboxamidobenzyl)-2-(3,5-bis-trifluoromethyl)-4,5-bis-(4-methoxyphenyl)-imidazole

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Overview

Replacement Information

Key Specifications Table

CAS #Empirical Formula
1054543-47-3C₃₃H₂₄F₆N₃O₃

Products

Catalog NumberPackaging Qty/Pack
178497-10MG Plastic ampoule 10 mg
Description
OverviewA cell-permeable imidazole compound that directly binds anti-apoptotic chaperone Hsc70 and its inducible homologue Hsp70 (Kd = 210 and 140 nM, respectively). Apoptozole is shown to effectively inhibit the proliferation of SK-OV-3, HCT-15, and A549 cancer cell lines (IC50 = 220, 250 and 130 nM, respectively) and induce 90% apoptotic cell death in P19 embryonic carcinoma and A549 lung cancer cultures after 12 hours drug treatment (1 µM).
Catalogue Number178497
Brand Family Calbiochem®
SynonymsHsp70 Inhibitor III, N-(4-Carboxamidobenzyl)-2-(3,5-bis-trifluoromethyl)-4,5-bis-(4-methoxyphenyl)-imidazole
References
ReferencesCho, H.J., et al. 2012. J. Am. Chem. Soc. 133, 20267.
Williams, D.R., et al. 2008. Angew. Chem. Int. Ed. 47, 7466.
Product Information
CAS number1054543-47-3
FormWhite solid
Hill FormulaC₃₃H₂₄F₆N₃O₃
Chemical formulaC₃₃H₂₄F₆N₃O₃
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Purity≥95% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalog Number GTIN
178497-10MG 04055977204827

Documentation

Apoptosis Activator VII, Apoptozole - CAS 1054543-47-3 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

Apoptosis Activator VII, Apoptozole - CAS 1054543-47-3 - Calbiochem Certificates of Analysis

TitleLot Number
178497

References

Reference overview
Cho, H.J., et al. 2012. J. Am. Chem. Soc. 133, 20267.
Williams, D.R., et al. 2008. Angew. Chem. Int. Ed. 47, 7466.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision27-June-2013 JSW
SynonymsHsp70 Inhibitor III, N-(4-Carboxamidobenzyl)-2-(3,5-bis-trifluoromethyl)-4,5-bis-(4-methoxyphenyl)-imidazole
DescriptionA cell-permeable imidazole compound that directly binds anti-apoptotic chaperone Hsc70 and its inducible homologue Hsp70 (Kd = 210 and 140 nM, respectively). Apoptozole is shown to effectively inhibit the proliferation of SK-OV-3, HCT-15, and A549 cancer cell lines (IC50 = 220, 250 and 130 nM, respectively) and induce 90% apoptotic cell death in P19 embryonic carcinoma and A549 lung cancer cultures after 12 h drug treatment (1 µM). Shown to suppress ubiquitination of mutant CFTR and promote membrane trafficking, and restore chloride channel activity.
FormWhite solid
Intert gas (Yes/No) Packaged under inert gas
CAS number1054543-47-3
Chemical formulaC₃₃H₂₄F₆N₃O₃
Structure formulaStructure formula
Purity≥95% by HPLC
SolubilityDMSO (50 mg/ml) or Ethanol (5 mg/ml)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity Standard Handling
ReferencesCho, H.J., et al. 2012. J. Am. Chem. Soc. 133, 20267.
Williams, D.R., et al. 2008. Angew. Chem. Int. Ed. 47, 7466.