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14-521M Arg Protein, active, human, 250 µg

Active, human, N-terminal His6-tagged recombinant human Arg, residues 38-end. For use in Kinase Assays.

14-521M
250 µg  Also available in 10 μg size (cat#14-521) and in bulk (cat#14-521-K).
Purchase on Sigma-Aldrich

Overview

Replacement Information
Description
Catalogue Number14-521M
Brand Family Upstate
Trade Name
  • Upstate
DescriptionArg Protein, active, human, 250 µg
OverviewN-terminal His6-tagged recombinant human Arg, residues 38-end.
References
Product Information
Quality LevelMQ300
Applications
ApplicationActive, human, N-terminal His6-tagged recombinant human Arg, residues 38-end. For use in Kinase Assays.
Key Applications
  • Kinase Assay
Biological Information
SourceHuman Arg expressed by baculovirus in Sf21 insect cells.
Entrez Gene Number
Entrez Gene SummaryThe gene product is a cytoplasmic tyrosine kinase which is closely related to but distinct from ABL1. The similarity of the proteins includes the tyrosine kinase domains and extends amino-terminal to include the SH2 and SH3 domains. This gene is expressed in both normal and tumor cells. Alternatively spliced transcript variants encoding different protein isoforms have been found for this gene.
Gene Symbol
  • ABL2
  • Abelson-related
  • ABLL
  • ARG
Protein TargetArg
Purification MethodNi2+/NTA-agarose
Target Sub-FamilyTK
UniProt Number
UniProt SummaryFUNCTION: SwissProt: P42684 # Regulates cytoskeleton remodeling during cell differentiation, cell division and cell adhesion. Localizes to dynamic actin structures, and phosphorylates CRK and CRKL, DOK1, and other proteins controlling cytoskeleton dynamics.
COFACTOR: Magnesium or manganese.
SIZE: 1182 amino acids; 128343 Da
SUBCELLULAR LOCATION: Cytoplasm.
TISSUE SPECIFICITY: Widely expressed.
PTM: Phosphorylated upon DNA damage, probably by ATM or ATR.
SIMILARITY: SwissProt: P42684 ## Belongs to the protein kinase superfamily. Tyr protein kinase family. ABL subfamily. & Contains 1 protein kinase domain. & Contains 1 SH2 domain. & Contains 1 SH3 domain.
Molecular Weight121.9 kDa
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality AssuranceRoutinely evaluated by phosphorylation of Abltide.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions6 months at -70°C
Packaging Information
Material Size250 µg
Material PackageAlso available in 10 μg size (cat#14-521) and in bulk (cat#14-521-K).
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalog Number GTIN
14-521M 04055977311242

Documentation

Related Products & Applications

Alternative Packsize

Catalog Number Description
14-521 Arg Protein, active, human, 10 µg

Product Families

Kinase & Phosphatase Products

Millipore offers a large portfolio of Kinases, Phophatases, Substrates, Inhibitors, Kits, reagents & tools for Signaling research. See below for a list of these products, in multiple pack sizes.
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Categories

Life Science Research > Proteins and Enzymes > Purified Kinases
Life Science Research > Drug Discovery and Development > Kinase & Phosphatase Screening > Purified Kinases