Millipore Sigma Vibrant Logo
Attention: We have moved. EMD Millipore products are no longer available for purchase on emdmillipore.com.Learn More

GF168 BMP-6 Protein, Human Recombinant

The Bone Morphogenetic Protein 6 also known as Vgr-1 protein, is one of at least 15 structurally & functionally related BMPs which are members of the TGF-β superfamily.

BMP-6 Protein, Human Recombinant MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
UniProt Number: P22004
View Products on Sigmaaldrich.com
GF168
10 µg  
Purchase on Sigma-Aldrich

Overview

Replacement Information

Key Specifications Table

SourcePurity
HEK293 CellsProduct is endotoxin free (< 0.1ng/μg of protein (<1EU/μg) and greater than 95% pure by SDS-PAGE gel and HPLC analyses
Description
Catalogue NumberGF168
DescriptionBMP-6 Protein, Human Recombinant
Alternate Names
  • Bone Morphogenetic Protein 6
  • BMP6
  • VRR-1
  • VG-1-related protein
Background InformationBone Morphogenetic Protein 6 (BMP-6), also known as Vgr-1, is one of at least 15 structurally and functionally related BMPs which are members of the transforming growth factor β (TGF-β) superfamily. TGF-β family members are key modulators of cell proliferation, differentiation, matrix synthesis, and apoptosis. As implied by their name, BMPs initiate, promote, and regulate the development, growth and remodeling of bone and cartilage. In addition to this role, BMPs are also involved in prenatal development and postnatal growth, remodeling and maintenance of a variety of other tissues and organs. Increasing evidence indicates that BMP-Smad signaling has a tumor suppressing activity and that BMPs can inhibit tumor growth. BMP-6 is abnormally expressed in breast cancer cell lines; however, its function in promoting breast cancer development is unknown. Recombinant human BMP-6 is a 26.2 kDa homodimeric glycoprotein consisting of two 117 amino acid subunits, which correspond to amino acid residues 397 to 513 of the full-length BMP-6 precursor.
References
Product Information
PresentationProduct is filtered through a 0.2 micron filter before lyophilization.
Quality LevelMQ100
Applications
ApplicationThe Bone Morphogenetic Protein 6 also known as Vgr-1 protein, is one of at least 15 structurally & functionally related BMPs which are members of the TGF-β superfamily.
Biological Information
PurityProduct is endotoxin free (< 0.1ng/μg of protein (<1EU/μg) and greater than 95% pure by SDS-PAGE gel and HPLC analyses
SourceHEK293 Cells
Cross ReactivityNone
UniProt Number
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality AssuranceBioactivity assay: Determined by its ability to induce alkaline phosphatase production by ATDC-5 cells. The expected ED50 this effect is 0.03-0.06 μg/ml.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsStore at -20°C for up to 6 months from date of receipt.
Packaging Information
Material Size10 µg
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalog Number GTIN
GF168 04053252691256

Documentation

BMP-6 Protein, Human Recombinant SDS

Title

Safety Data Sheet (SDS) 

BMP-6 Protein, Human Recombinant Certificates of Analysis

TitleLot Number
Recombinant Human BMP-6 - 2382649 2382649
Recombinant Human -2719439 2719439
Recombinant Human -2734721 2734721
Recombinant Human BMP-6 - 2092749 2092749
Recombinant Human BMP-6 - 2202474 2202474
Recombinant Human BMP-6 - 2211058 2211058
Recombinant Human BMP-6 - 2228118 2228118
Recombinant Human BMP-6 - 2280910 2280910
Recombinant Human BMP-6 - 2297278 2297278
Recombinant Human BMP-6 - 3207608 3207608
Show more

Related Products & Applications

Product Families

Cytokines and Growth Factors

EMD Millipore offers a comprehensive range of highly purified bioactive cytokines and growth factors for use in human, mouse, and rat cell culture, stem cell differentiation and ELISA studies.
Learn More >>

Categories

Life Science Research > Proteins and Enzymes > Cytokines & Growth Factors
Life Science Research > Cell Culture and Systems > Cell Culture Media and Supplements > Cell Culture Supplements > Cytokines & Growth Factors