506416 Sigma-AldrichBeclin-1 Activator II, retro-inverso TAT-Beclin-1 - Calbiochem
Beclin-1 Activator II, retro-inverso TAT-Beclin-1 is a cell-permeable, all-D-amino acid autophagy-inducing peptide based on the retro-inverso sequence of Tat-Beclin1 (Cat. No. 506048).
More>> Beclin-1 Activator II, retro-inverso TAT-Beclin-1 is a cell-permeable, all-D-amino acid autophagy-inducing peptide based on the retro-inverso sequence of Tat-Beclin1 (Cat. No. 506048). Less<<MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Synonyms: (D)-H₂N-RRRQRRKKRGY-GG-TGFEGDHWIEFTANFVNT-CO₂H, Atg6 Activator II, Beclin-1-GAPR-1 Interaction Blocker II, Vps30 Activator II
Recommended Products
Overview
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Key Specifications Table
| Empirical Formula |
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| C₁₆₄H₂₅₁N₅₇O₄₅ |
Products
| Catalog Number | Packaging | Qty/Pack | |
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| 5.06416.0001 | Glass bottle | 5 mg |
| Description | |
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| Overview | A cell-permeable, all-D-amino acid autophagy-inducing peptide based on the retro-inverso sequence of Tat-Beclin1 (Cat. No. 506048) that is expected to be more resistant to proteolytic degradation than Tat-Beclin1 and is shown to be more potent than Tat-Beclin1 in inducing autophagy in muscle, heart, and pancreas tissues in 6-wk-old GFP-LC3 transgenic mice (20 mg/kg i.p.) in vivo. Only the retro-inverso peptide, but not Tat-Beclin1, is effective in reducing autophagy substrate p62 level in the brain tissue of 5-d-old neontal GFP-LC3 mice (20 mg/kg i.p.). The retro-inverso peptide treatment is also reported to greatly reduce brain viral titre in neonatal mice subjected to West Nile Virus infection. |
| Catalogue Number | 506416 |
| Brand Family | Calbiochem® |
| Synonyms | (D)-H₂N-RRRQRRKKRGY-GG-TGFEGDHWIEFTANFVNT-CO₂H, Atg6 Activator II, Beclin-1-GAPR-1 Interaction Blocker II, Vps30 Activator II |
| References | |
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| References | Shoji-Kawata, S., et al. 2013. Nature. 494, 201. |
| Product Information | |
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| Declaration | Sold under license of US Patent 8,722,628. |
| Form | White powder |
| Formulation | Supplied as a trifluoroacetate salt. |
| Hill Formula | C₁₆₄H₂₅₁N₅₇O₄₅ |
| Chemical formula | C₁₆₄H₂₅₁N₅₇O₄₅ |
| Hygroscopic | Hygroscopic |
| Reversible | Y |
| Quality Level | MQ100 |
| Biological Information | |
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| Primary Target | GAPR-1/GLIPR2 |
| Purity | ≥95% by HPLC |
| Physicochemical Information | |
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| Cell permeable | Y |
| Peptide Sequence | (D)-H-arg-arg-arg-gln-arg-arg-lys-lys-arg-Gly-tyr~Gly-Gly~thr-Gly-phe-glu-Gly-asp-his-trp-ile-glu-phe-thr-ala-asn-phe-val-asn-thr-OH |
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| Toxicological Information |
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| Safety Information according to GHS |
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| Product Usage Statements |
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| Packaging Information | |
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| Packaged under inert gas | Packaged under inert gas |
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| Specifications |
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| Global Trade Item Number | |
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| Catalog Number | GTIN |
| 5.06416.0001 | 04055977243321 |
Documentation
Beclin-1 Activator II, retro-inverso TAT-Beclin-1 - Calbiochem SDS
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References
| Reference overview |
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| Shoji-Kawata, S., et al. 2013. Nature. 494, 201. |
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Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.
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