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506239 Bupropion Hydrochloride - CAS 31677-93-7 - Calbiochem

Bupropion is a non-selective inhibitor of dopamine and noradrenalin transporters. Also an antagonist for neuronal nicotinic acetylcholine receptors (nAChrs).

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Dopamine and noradrenalin Transporter Inibitor, Bupropion

Primary Target: DAT/NET
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Overview

Replacement Information

Key Specifications Table

CAS #Empirical Formula
31677-93-7C₁₃H₁₈ClNO·HCl

Products

Catalog NumberPackaging Qty/Pack
5.06239.0001 Glass bottle 50 mg
Description
OverviewA non-selective inhibitor of dopamine and noradrenalin transporters (Ki = 1.4, 2.8 and 45 µM for dopamine, noradrenalin, and serotonin transporters respectively). Also an antagonist for neuronal nicotinic acetylcholine receptors (nAChrs) (IC50 = 1.8 µM at α2β2 receptor). Clinically used as an antidepressant and smoking seceasion drug. Used in nicotinic addiction and depression studies.
Catalogue Number506239
Brand Family Calbiochem®
SynonymsDopamine and noradrenalin Transporter Inibitor, Bupropion
References
ReferencesBudzynska, B. et al. 2011 Pharmacol. Rep. 63, 71.
Dwoskin, P., et al. 2006. CNS Drug Rev. 12, 178.
Soroko, F., et al. 1977. J. Pharm. Pharmacol. 29, 769.
Product Information
CAS number31677-93-7
FormWhite solid
Hill FormulaC₁₃H₁₈ClNO·HCl
Chemical formulaC₁₃H₁₈ClNO·HCl
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetDAT/NET
Primary Target K<sub>i</sub>1.4 µ
Purity≥99% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
R PhraseR: 22

Harmful if swallowed.
S PhraseS: 46

If swallowed, seek medical advice immediately and show this container or label.
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity Harmful
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalog Number GTIN
5.06239.0001 04055977243185

Documentation

Bupropion Hydrochloride - CAS 31677-93-7 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

References

Reference overview
Budzynska, B. et al. 2011 Pharmacol. Rep. 63, 71.
Dwoskin, P., et al. 2006. CNS Drug Rev. 12, 178.
Soroko, F., et al. 1977. J. Pharm. Pharmacol. 29, 769.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision27-September-2013 JSW
SynonymsDopamine and noradrenalin Transporter Inibitor, Bupropion
DescriptionA non-selective inhibitor of dopamine and noradrenalin transporters (Ki = 1.4, 2.8 and 45 µM for dopamine, noradrenalin, and serotonin transporters respectively). Also an antagonist for neuronal nicotinic acetylcholine receptors (nAChrs) (IC50 = 1.8 µM at α2β2 receptor). Clinically used as an antidepressant and smoking seceasion drug. Used in nicotinic addiction and depression studies.
FormWhite solid
CAS number31677-93-7
Chemical formulaC₁₃H₁₈ClNO·HCl
Structure formulaStructure formula
Purity≥99% by HPLC
SolubilityH₂O
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Harmful
ReferencesBudzynska, B. et al. 2011 Pharmacol. Rep. 63, 71.
Dwoskin, P., et al. 2006. CNS Drug Rev. 12, 178.
Soroko, F., et al. 1977. J. Pharm. Pharmacol. 29, 769.