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217505 CBP-CREB Interaction Inhibitor - CAS 92-78-4 - Calbiochem

The CBP-CREB Interaction Inhibitor, also referenced under CAS 92-78-4, controls the biological activity of CBP-CREB.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Luciferase Inhibitor III, N-(4-Chlorophenyl)-3-hydroxy-2-naphthamide, KIX-KID Interaction Inhibitor

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217505
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Overview

Replacement Information

Key Specifications Table

CAS #Empirical Formula
92-78-4C₁₇H₁₂ClNO₂

Products

Catalog NumberPackaging Qty/Pack
217505-250MG Glass bottle 250 mg
Description
OverviewA cell-permeable naphthamide compound that effectively blocks the interaction between the KIX domain of CBP and the KID domain of CREB in HEK293T-based and cell-free Renilla luciferase (RLuc) complementation assays (IC50 = 2.26 and 2.9 µM, respectively) by directly binding to CBP's KIX domain (Kd ~8.6 µM using a recombinant KIX). Shown to inhibit CRE- (cAMP response element) dependent transcription activity induced by forskolin (Cat. No. 344270) in a HEK293T-based RLuc reporter assay (IC50 <2.5 µM), while exhibiting little effect against the KID-independent CREB-VP16 transcription activity. Also reported to inhibit the enzymatic activity of Firefly luciferase (IC50 ~1 µM), but not that of RLuc.
Catalogue Number217505
Brand Family Calbiochem®
SynonymsLuciferase Inhibitor III, N-(4-Chlorophenyl)-3-hydroxy-2-naphthamide, KIX-KID Interaction Inhibitor
References
ReferencesLi, B.X. and Xiao, X., 2009. ChemBioChem 10, 2721.
Best, J.L., et al. 2004. Proc. Natl. Acad. Sci. USA 101, 17622.
Product Information
CAS number92-78-4
FormBeige solid
Hill FormulaC₁₇H₁₂ClNO₂
Chemical formulaC₁₇H₁₂ClNO₂
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Purity≥97% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalog Number GTIN
217505-250MG 04055977219371

Documentation

CBP-CREB Interaction Inhibitor - CAS 92-78-4 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

CBP-CREB Interaction Inhibitor - CAS 92-78-4 - Calbiochem Certificates of Analysis

TitleLot Number
217505

References

Reference overview
Li, B.X. and Xiao, X., 2009. ChemBioChem 10, 2721.
Best, J.L., et al. 2004. Proc. Natl. Acad. Sci. USA 101, 17622.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision04-August-2010 RFH
SynonymsLuciferase Inhibitor III, N-(4-Chlorophenyl)-3-hydroxy-2-naphthamide, KIX-KID Interaction Inhibitor
DescriptionA cell-permeable naphthamide compound that effectively blocks the interaction between the KIX domain of CBP and the KID domain of CREB in HEK293T-based and cell-free Renilla luciferase (RLuc) complementation assays (IC50 = 2.26 and 2.9 µM, respectively) by directly binding to CBP's KIX domain (Kd ~8.6 µM using a recombinant KIX). Shown to inhibit CRE- (cAMP response element) dependent transcription activity induced by forskolin (Cat. No. 344270) in a HEK293T-based RLuc reporter assay (IC50 <2.5 µM), while exhibiting little effect against the KID-independent CREB-VP16 transcription activity. Also reported to inhibit the enzymatic activity of Firefly luciferase (IC50 ~1 µM), but not that of RLuc.
FormBeige solid
Intert gas (Yes/No) Packaged under inert gas
CAS number92-78-4
Chemical formulaC₁₇H₁₂ClNO₂
Structure formulaStructure formula
Purity≥97% by HPLC
SolubilityDMSO (100 mg/ml)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity Standard Handling
ReferencesLi, B.X. and Xiao, X., 2009. ChemBioChem 10, 2721.
Best, J.L., et al. 2004. Proc. Natl. Acad. Sci. USA 101, 17622.