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03-189 CBP (catalytic domain) human recombinant

CBP (catalytic domain) human recombinant protein expressed in E. Coli.

CBP (catalytic domain) human recombinant MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Key Applications: Enzyme Assays UniProt Number: Q92793
03-189
100 µg  
Purchase on Sigma-Aldrich

Overview

Replacement Information

Key Specifications Table

Key ApplicationsSpeciesUni Prot Number
Enzyme AssaysHuman Q92793
Description
Catalogue Number03-189
Brand Family Upstate
Trade Name
  • Upstate
DescriptionCBP (catalytic domain) human recombinant
OverviewCBP (catalytic domain) human recombinant expressed in E. Coli
Background InformationAlthough originally termed histone acetyltransferases (HATs) for their lysine acetylation activity on histone N-terminal tails, p300 and its paralogue, CBP, have been shown to acetylate a variety of non-histone proteins including p53, DNA polymerase ß and nuclear import factors. p300/CBP acetylations play regulatory roles in transcription, DNA repair and replication, the cell cycle, p53 turnover, and nuclear import. In addition to functions which overlap with those of CBP, p300 has a number of unique functions, including a role in the induction of p21Waf1/Cip1 cell cycle inhibitor.
References
Product Information
FormatPurified
PresentationIn liquid containing 50 mM Tris/HCl, pH 8.0, 0.1 mM EDTA, 10% glycerol. Frozen solution.
Quality LevelMQ100
Applications
ApplicationCBP (catalytic domain) human recombinant protein expressed in E. Coli.
Key Applications
  • Enzyme Assays
Application NotesAcetyltransferase assays
Biological Information
PurityPurity >65% by SDS-PAGE
SourceCatalytic domain (residues 1319-1710) of human CBP histone acetyltransferase
Specific Activity[Varies with lot. For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.] XXX 250 pmol/min/µg assayed as production of CoA-SH from AcCoA in the presence of a peptide comprising human p53 residues 368-386. CoA-SH is determined colorimetrically by reaction with DTNB (5,5′-Dithiobis (2-nitrobenzoic acid).
UniProt Number
Molecular Weight~48 kDa
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsStable for 12 months at -80°C from date of receipt. Avoid multiple freeze/thaw cycles.
Packaging Information
Material Size100 µg
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalog Number GTIN
03-189 04053252550836

Documentation

CBP (catalytic domain) human recombinant Certificates of Analysis

TitleLot Number
CBP (catalytic domain) human -2809583 2809583
CBP (catalytic domain) human recombinant - 2390574 2390574
CBP (catalytic domain) human recombinant - 3201380 3201380
CBP (catalytic domain) human recombinant - 3537859 3537859
CBP (catalytic domain) human recombinant - 3722793 3722793
CBP (catalytic domain) human recombinant - 3764141 3764141
CBP (catalytic domain) human recombinant - Q2022474 Q2022474
CBP (catalytic domain) human recombinant -2522058 2522058
CBP (catalytic domain) human recombinant, Recombinant Protein 2926418

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