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227016 CCR2 Antagonist - CAS 445479-97-0 - Calbiochem

The CCR2 Antagonist, also referenced under CAS 445479-97-0, controls the biological activity of CCR2.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 2-((Isopropylaminocarbonyl)amino)-N-(2-((cis-2-((4-(methylthio)benzoyl)amino)cyclohexyl)amino)-2-oxoethyl)-5-(trifluoromethyl)-benzamide, CC Chemokine Receptor 2 Antagonist

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227016
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Overview

Replacement Information

Key Specifications Table

CAS #Empirical Formula
445479-97-0C₂₈H₃₄F₃N₅O₄S

Products

Catalog NumberPackaging Qty/Pack
227016-5MG Plastic ampoule 5 mg
Description
OverviewA cis-diamidocyclohexyl urea compound that potently competes against MCP-1 binding to CCR2 (IC50 = 5.1 nM) and effectively inhibits MCP-1/CCR2-mediated PBMCs Ca+2 flux and chemotaxis (IC50 = 18 and 1 nM, respectively), while showing much less effect against eotaxin binding to CCR3 (37% inhibition at 10 µM). Mutageneis analysis indicates CCR2 Thr292 is critical in maintaining the high affinity antagonist binding.
Catalogue Number227016
Brand Family Calbiochem®
Synonyms2-((Isopropylaminocarbonyl)amino)-N-(2-((cis-2-((4-(methylthio)benzoyl)amino)cyclohexyl)amino)-2-oxoethyl)-5-(trifluoromethyl)-benzamide, CC Chemokine Receptor 2 Antagonist
References
ReferencesCherney, R.J., et al. 2008. J. Med. Chem. 51, 721.
Product Information
CAS number445479-97-0
FormWhite solid
Hill FormulaC₂₈H₃₄F₃N₅O₄S
Chemical formulaC₂₈H₃₄F₃N₅O₄S
Hygroscopic Hygroscopic
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Purity≥97% by HPLC (racemic mixture)
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
S PhraseS: 22-24/25-36/37/39

Do not breathe dust.
Avoid contact with skin and eyes.
Wear suitable protective clothing, gloves and eye/face protection.
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalog Number GTIN
227016-5MG 04055977200553

Documentation

CCR2 Antagonist - CAS 445479-97-0 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

CCR2 Antagonist - CAS 445479-97-0 - Calbiochem Certificates of Analysis

TitleLot Number
227016

References

Reference overview
Cherney, R.J., et al. 2008. J. Med. Chem. 51, 721.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision19-August-2011 JSW
Synonyms2-((Isopropylaminocarbonyl)amino)-N-(2-((cis-2-((4-(methylthio)benzoyl)amino)cyclohexyl)amino)-2-oxoethyl)-5-(trifluoromethyl)-benzamide, CC Chemokine Receptor 2 Antagonist
DescriptionA cis-diamidocyclohexyl urea compound that potently competes against MCP-1 binding to CCR2 (IC50 = 5.1 nM) and effectively inhibits MCP-1/CCR2-mediated PBMCs Ca+2 flux and chemotaxis (IC50 = 18 and 1 nM, respectively), while showing much less effect against eotaxin binding to CCR3 (37% inhibition at 10 µM). Mutageneis analysis indicates CCR2 Thr292 is critical in maintaining the high affinity antagonist binding.
FormWhite solid
Intert gas (Yes/No) Packaged under inert gas
CAS number445479-97-0
Chemical formulaC₂₈H₃₄F₃N₅O₄S
Structure formulaStructure formula
Purity≥97% by HPLC (racemic mixture)
SolubilityDMSO (60 mg/ml) or Ethanol (6 mg/ml). Gentle warming, rapid stirring, and/or sonication may be required for complete solubilization.
Storage Protect from light
+2°C to +8°C
Hygroscopic
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesCherney, R.J., et al. 2008. J. Med. Chem. 51, 721.