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219670 CFTR Inhibitor-172 - CAS 307510-92-5 - Calbiochem

CFTR Inhibitor-172, CAS 307510-92-5, is a cell-permeable, potent, reversible, rapid, and voltage-independent inhibitor of CFTR-mediated Cl- transport in human airway cells (Ki ~ 300 nM).

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 3-[(3-Trifluoromethyl)phenyl]-5-[(4-carboxyphenyl)methylene]-2-thioxo-4-thiazolidinone, CFTRinh-172

Primary Target: CFTR
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219670
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Overview

Replacement Information

Key Specifications Table

CAS #Empirical Formula
307510-92-5C₁₈H₁₀F₃NO₃S₂

Products

Catalog NumberPackaging Qty/Pack
219670-5MG Plastic ampoule 5 mg
Description
OverviewA cell-permeable 2-thio-4-thiazolidinone compound that acts as a potent, reversible, rapid, and voltage-independent inhibitor of CFTR (cystic fibrosis transmembrane conductance regulator)-mediated Cl- transport in human airway cells (Ki ~ 300 nM). It does not prevent elevation of cellular cAMP, nor does it inhibit non-CFTR Cl- channels, MDR-1, ATP-sensitive K+ channels, or a series of other transporters even at concentrations as high as 5 µM. Shown to block cholera toxin-induced intestinal fluid secretion in mice. May be also useful for reducing intestinal fluid loss in other secretory diarrheas. Also available as a 50 mM solution in DMSO (Cat. No. 219674).
Catalogue Number219670
Brand Family Calbiochem®
Synonyms3-[(3-Trifluoromethyl)phenyl]-5-[(4-carboxyphenyl)methylene]-2-thioxo-4-thiazolidinone, CFTRinh-172
References
ReferencesYang, H., et al. 2003. J. Biol. Chem. 278, 35079.
Al-Awqati, Q., et al. 2002. J. Clin. Invest. 110, 1599.
Ma, T., et al. 2002. J. Clin. Invest. 110, 1651.
Product Information
CAS number307510-92-5
ATP CompetitiveN
FormYellow solid
Hill FormulaC₁₈H₁₀F₃NO₃S₂
Chemical formulaC₁₈H₁₀F₃NO₃S₂
ReversibleY
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetCFTR
Primary Target K<sub>i</sub>~ 300 nM against CFTR (cystic fibrosis transmembrane conductance regulator)-mediated Cl- transport in human airway cells
Purity≥95% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalog Number GTIN
219670-5MG 04055977201550

Documentation

CFTR Inhibitor-172 - CAS 307510-92-5 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

CFTR Inhibitor-172 - CAS 307510-92-5 - Calbiochem Certificates of Analysis

TitleLot Number
219670

References

Reference overview
Yang, H., et al. 2003. J. Biol. Chem. 278, 35079.
Al-Awqati, Q., et al. 2002. J. Clin. Invest. 110, 1599.
Ma, T., et al. 2002. J. Clin. Invest. 110, 1651.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision05-April-2011 RFH
Synonyms3-[(3-Trifluoromethyl)phenyl]-5-[(4-carboxyphenyl)methylene]-2-thioxo-4-thiazolidinone, CFTRinh-172
DescriptionA cell-permeable 2-thio-4-thiazolidinone compound that acts as a potent, reversible, rapid, and voltage-independent inhibitor of CFTR (cystic fibrosis transmembrane conductance regulator)-mediated Cl- transport in human airway cells (Ki ~ 300 nM). It does not prevent elevation of cellular cAMP, nor does it inhibit non-CFTR Cl- channels, MDR-1, ATP-sensitive K+ channels, or a series of other transporters even at concentrations as high as 5 µM. Shown to block cholera toxin-induced intestinal fluid secretion in mice. May be also useful for reducing intestinal fluid loss in other secretory diarrheas.
FormYellow solid
Intert gas (Yes/No) Packaged under inert gas
CAS number307510-92-5
Chemical formulaC₁₈H₁₀F₃NO₃S₂
Structure formulaStructure formula
Purity≥95% by HPLC
SolubilityDMSO (5 mg/ml)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesYang, H., et al. 2003. J. Biol. Chem. 278, 35079.
Al-Awqati, Q., et al. 2002. J. Clin. Invest. 110, 1599.
Ma, T., et al. 2002. J. Clin. Invest. 110, 1651.