219677 Sigma-AldrichCFTR Inhibitor IV, PPQ-102 - CAS 931706-15-9 - Calbiochem
CFTR Inhibitor IV, PPQ-102, CAS 931706-15-9, is a cell-permeable inhibitor of CFTR-mediated chloride current in a reversible and voltage-independent manner.
More>> CFTR Inhibitor IV, PPQ-102, CAS 931706-15-9, is a cell-permeable inhibitor of CFTR-mediated chloride current in a reversible and voltage-independent manner. Less<<MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Synonyms: 7,9-Dimethyl-11-phenyl-6-(5-methylfuran-2-yl)-5,6-dihydro-pyrimido-[4ʹ,5ʹ-3,4]pyrrolo[1,2-a]quinoxaline-8,10-(7H,9H)-dione, Cystic Fibrosis Transmembrane Conductance Regulator Inhibitor IV
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Overview
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Key Specifications Table
| CAS # | Empirical Formula |
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| 931706-15-9 | C₂₆H₂₂N₄O₃ |
Products
| Catalog Number | Packaging | Qty/Pack | |
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| 219677-10MG | Glass bottle | 10 mg |
| Description | |
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| Overview | A cell-permeable pyrimido-pyrrolo-quinoxalinedione (PPQ) compound that targets the intracellular nucleotide binding domain(s) of CFTR and inhibits CFTR-mediated chloride current in a reversible and voltage-independent manner. Single channel recordings of CFTR-expressing FRT cells upon forskolin (Cat. No. 344270) and IBMX (Cat. No. 410957) stimulation indicate that the nature of PPQ-102 inhibition is due to a stabilization of the channels in a closed state (7.8- vs. 0.4-fold increase of mean channel close vs. open time, respectively, with 1 µM PPQ-102). PPQ-102 at 5 µM is shown to completely prevent Sp-8-Br-cAMP- (Cat. No. 116818) induced cysts formation and reduce the size of preformed cysts in an ex vivo murine neonatal kidney organ culture. |
| Catalogue Number | 219677 |
| Brand Family | Calbiochem® |
| Synonyms | 7,9-Dimethyl-11-phenyl-6-(5-methylfuran-2-yl)-5,6-dihydro-pyrimido-[4ʹ,5ʹ-3,4]pyrrolo[1,2-a]quinoxaline-8,10-(7H,9H)-dione, Cystic Fibrosis Transmembrane Conductance Regulator Inhibitor IV |
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| References | Tradtrantip, L., et al. 2009. J. Med. Chem. 52, 6447. |
| Product Information | |
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| CAS number | 931706-15-9 |
| Form | White crystalline solid |
| Hill Formula | C₂₆H₂₂N₄O₃ |
| Chemical formula | C₂₆H₂₂N₄O₃ |
| Structure formula Image | |
| Quality Level | MQ100 |
| Applications | |
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| Application | CFTR Inhibitor IV, PPQ-102, CAS 931706-15-9, is a cell-permeable inhibitor of CFTR-mediated chloride current in a reversible and voltage-independent manner. |
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| Purity | ≥95% by HPLC |
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| Packaged under inert gas | Packaged under inert gas |
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| Specifications |
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| Global Trade Item Number | |
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| Catalog Number | GTIN |
| 219677-10MG | 04055977200959 |
Documentation
CFTR Inhibitor IV, PPQ-102 - CAS 931706-15-9 - Calbiochem SDS
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CFTR Inhibitor IV, PPQ-102 - CAS 931706-15-9 - Calbiochem Certificates of Analysis
| Title | Lot Number |
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| 219677 |
References
| Reference overview |
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| Tradtrantip, L., et al. 2009. J. Med. Chem. 52, 6447. |