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208745 Calpain Inhibitor VI - CAS 190274-53-4 - Calbiochem

The Calpain Inhibitor VI, also referenced under CAS 190274-53-4, controls the biological activity of Calpain. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: N-(4-Fluorophenylsulfonyl)-L-valyl-L-leucinal, SJA6017

Primary Target: µ-calpain
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208745
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Overview

Replacement Information

Key Specifications Table

CAS #Empirical Formula
190274-53-4C₁₇H₂₅FN₂O₄S

Products

Catalog NumberPackaging Qty/Pack
208745-1MG Plastic ampoule 1 mg
208745-5MG Plastic ampoule 5 mg
Description
OverviewA potent, cell-permeable, reversible inhibitor of calpain (IC50 = 7.5 nM for µ-calpain and 78 nM for m-calpain). Also potently inhibits cathepsin B (IC50 = 15 nM) and L (IC50 = 1.6 nM). Reduces bFGF-induced angiogenesis in rat cornea and prevents selenite cataract formation. Reduces A23187-induced nuclear opacity and proteolysis of crystallins and α-spectrin in cultured lenses.
Catalogue Number208745
Brand Family Calbiochem®
SynonymsN-(4-Fluorophenylsulfonyl)-L-valyl-L-leucinal, SJA6017
References
ReferencesInoue, J., et al. 2003. J. Med. Chem. 46, 868.
Tamada, Y., et al. 2001. Curr. Eye Res. 22, 280.
Mathur, P., et al. 2000. Curr. Eye Res. 21, 926.
Nath, R., et al. 2000. Biochem. Biophys. Res. Commun. 274, 16.
Tamada, Y., et al. 2000. J. Ocul. Pharmacol. Ther. 16, 271.
Fukiage, C., et al. 1998. Curr. Eye Res. 17, 623.
Fukiage, C., et al. 1997. Biochim. Biophys. Acta 1361, 304.
Product Information
CAS number190274-53-4
ATP CompetitiveN
DeclarationSold under license of U.S. Patent 6,551,999
FormWhite lyophilized solid
Hill FormulaC₁₇H₂₅FN₂O₄S
Chemical formulaC₁₇H₂₅FN₂O₄S
ReversibleY
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary Targetµ-calpain
Primary Target IC<sub>50</sub>7.5 nM for µ-calpain and 78 nM for m-calpain; 15 nM and 1.6 nM against cathepsin B and L, respectively
Purity≥97% by HPLC
Physicochemical Information
Cell permeableY
Peptide Sequence4-Fluorophenylsulfonyl-Val-Leu-CHO
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze at -20°C. Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalog Number GTIN
208745-1MG 04055977202816
208745-5MG 04055977202823

Documentation

Calpain Inhibitor VI - CAS 190274-53-4 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

Calpain Inhibitor VI - CAS 190274-53-4 - Calbiochem Certificates of Analysis

TitleLot Number
208745

References

Reference overview
Inoue, J., et al. 2003. J. Med. Chem. 46, 868.
Tamada, Y., et al. 2001. Curr. Eye Res. 22, 280.
Mathur, P., et al. 2000. Curr. Eye Res. 21, 926.
Nath, R., et al. 2000. Biochem. Biophys. Res. Commun. 274, 16.
Tamada, Y., et al. 2000. J. Ocul. Pharmacol. Ther. 16, 271.
Fukiage, C., et al. 1998. Curr. Eye Res. 17, 623.
Fukiage, C., et al. 1997. Biochim. Biophys. Acta 1361, 304.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision19-February-2014 JSW
SynonymsN-(4-Fluorophenylsulfonyl)-L-valyl-L-leucinal, SJA6017
DescriptionA cell-permeable peptide aldehyde that acts as a potent and reversible inhibitor of calpain (IC50 = 7.5 nM for µ-calpain and 78 nM for m-calpain). Also potently inhibits cathepsin B (IC50 = 15 nM) and cathepsin L (IC50 = 1.6 nM). Reduces βFGF-induced angiogenesis in rat cornea and prevents selenite cataract formation in rats. Reduces A23187-induced nuclear opacity and proteolysis of crystallins and α-spectrin in cultured rat lenses.
FormWhite lyophilized solid
Intert gas (Yes/No) Packaged under inert gas
CAS number190274-53-4
Chemical formulaC₁₇H₂₅FN₂O₄S
Peptide Sequence4-Fluorophenylsulfonyl-Val-Leu-CHO
Structure formulaStructure formula
Purity≥97% by HPLC
SolubilityDMSO (5 mg/ml)
Storage Protect from light
-20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze at -20°C. Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesInoue, J., et al. 2003. J. Med. Chem. 46, 868.
Tamada, Y., et al. 2001. Curr. Eye Res. 22, 280.
Mathur, P., et al. 2000. Curr. Eye Res. 21, 926.
Nath, R., et al. 2000. Biochem. Biophys. Res. Commun. 274, 16.
Tamada, Y., et al. 2000. J. Ocul. Pharmacol. Ther. 16, 271.
Fukiage, C., et al. 1998. Curr. Eye Res. 17, 623.
Fukiage, C., et al. 1997. Biochim. Biophys. Acta 1361, 304.