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208925 Camptothecin, Camptotheca acuminata - CAS 2114454 - Calbiochem

A cell-permeable DNA topoisomerase I inhibitor.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 4-Ethyl-4-hydroxy-1H-pyrano[3ʹ,4ʹ:6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)dione

Primary Target: DNA topoisomerase 1
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208925
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Overview

Replacement Information

Key Specifications Table

CAS #Empirical Formula
7689-03-4C₂₀H₁₆N₂O₄

Products

Catalog NumberPackaging Qty/Pack
208925-50MG Alu drum 50 mg
Description
OverviewA cell-permeable DNA topoisomerase I inhibitor. Exhibits anti-leukemic and antitumor properties. Induces apoptosis in HL-60 cells and mouse thymocytes. Arrests cells at the G2/M phase.
Catalogue Number208925
Brand Family Calbiochem®
Synonyms4-Ethyl-4-hydroxy-1H-pyrano[3ʹ,4ʹ:6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)dione
References
ReferencesJones, C.B., et al. 1997. Cancer Chemother. Pharmacol. 40, 475.
Staron, K., et al. 1994. Carcinogenesis 15, 2953.
Tanizawa, A., et al. 1994. J. Natl. Cancer Inst. 86, 836.
Gorczyca, W., et al. 1993. Toxicol. Lett. 67, 249.
Onishi, Y., et al. 1993. Biochim. Biophys. Acta 1175, 147.
Pantazis, P., et al. 1993. Int. J. Cancer 53, 863.
Morham, S.G., and Shuman, S. 1992. J. Biol. Chem. 267, 15984.
Hertzberg, R.P., et al. 1990. Biochem. J. 28, 4629.
Hertzberg, R.P., et al. 1990. J. Biol. Chem. 265, 19287.
Hsiang, Y.H., et al. 1985. J. Biol. Chem. 260, 14873.
Product Information
CAS number7689-03-4
ATP CompetitiveN
FormPale yellow solid
Hill FormulaC₂₀H₁₆N₂O₄
Chemical formulaC₂₀H₁₆N₂O₄
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetDNA topoisomerase 1
Purity≥95% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
RTECSUQ0492000
Safety Information
R PhraseR: 25-36/37/38-46

Toxic if swallowed.
Irritating to eyes, respiratory system and skin.
May cause heritable genetic damage.
S PhraseS: 22-26-36/37/39-45

Do not breathe dust.
In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
Wear suitable protective clothing, gloves and eye/face protection.
In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Toxic & Carcinogenic / Teratogenic
Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
Storage +2°C to +8°C
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 months at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalog Number GTIN
208925-50MG 04055977219128

Documentation

Camptothecin, Camptotheca acuminata - CAS 2114454 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

Camptothecin, Camptotheca acuminata - CAS 2114454 - Calbiochem Certificates of Analysis

TitleLot Number
208925

References

Reference overview
Jones, C.B., et al. 1997. Cancer Chemother. Pharmacol. 40, 475.
Staron, K., et al. 1994. Carcinogenesis 15, 2953.
Tanizawa, A., et al. 1994. J. Natl. Cancer Inst. 86, 836.
Gorczyca, W., et al. 1993. Toxicol. Lett. 67, 249.
Onishi, Y., et al. 1993. Biochim. Biophys. Acta 1175, 147.
Pantazis, P., et al. 1993. Int. J. Cancer 53, 863.
Morham, S.G., and Shuman, S. 1992. J. Biol. Chem. 267, 15984.
Hertzberg, R.P., et al. 1990. Biochem. J. 28, 4629.
Hertzberg, R.P., et al. 1990. J. Biol. Chem. 265, 19287.
Hsiang, Y.H., et al. 1985. J. Biol. Chem. 260, 14873.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision15-July-2009 RFH
Synonyms4-Ethyl-4-hydroxy-1H-pyrano[3ʹ,4ʹ:6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)dione
DescriptionA cell-permeable, reversible DNA topoisomerase I inhibitor that binds to and stabilizes the topoisomerase-DNA covalent complex. Possesses antileukemic and antitumor properties. Inhibits Tat-mediated transactivation of HIV-1. Cytostatic for non-tumorigenic cells but cytotoxic for tumorigenic cells. Induces apoptosis of HL-60 cells and mouse thymocytes.
FormPale yellow solid
CAS number7689-03-4
RTECSUQ0492000
Chemical formulaC₂₀H₁₆N₂O₄
Structure formulaStructure formula
Purity≥95% by HPLC
SolubilityDMSO (10 mg/ml) and MeOH (40 mg/ml). Stock solutions made with methanol will remain cloudy.
Storage +2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 months at -20°C.
Toxicity Toxic & Carcinogenic / Teratogenic
Merck USA index14, 1735
ReferencesJones, C.B., et al. 1997. Cancer Chemother. Pharmacol. 40, 475.
Staron, K., et al. 1994. Carcinogenesis 15, 2953.
Tanizawa, A., et al. 1994. J. Natl. Cancer Inst. 86, 836.
Gorczyca, W., et al. 1993. Toxicol. Lett. 67, 249.
Onishi, Y., et al. 1993. Biochim. Biophys. Acta 1175, 147.
Pantazis, P., et al. 1993. Int. J. Cancer 53, 863.
Morham, S.G., and Shuman, S. 1992. J. Biol. Chem. 267, 15984.
Hertzberg, R.P., et al. 1990. Biochem. J. 28, 4629.
Hertzberg, R.P., et al. 1990. J. Biol. Chem. 265, 19287.
Hsiang, Y.H., et al. 1985. J. Biol. Chem. 260, 14873.