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533851 Cancer Stemness Inhibitor, BBI608 - CAS 83280-65-3 - Calbiochem

A cell-permeable compound that diminishes gene expression and self-renewal in stemness high cancer cells. Blocks cancer relapse and metastasis.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 2-Acetyl-4H,9H-naphtho[2,3-b]furan-4,9-dione, 2-Acetylnaphtho[2,3-b]furan-4,9-dione, Spherogenesis Blocker, BBI-608

Primary Target: STAT3
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Overview

Replacement Information

Key Specifications Table

CAS #Empirical Formula
83280-65-3C₁₄H₈O₄

Products

Catalog NumberPackaging Qty/Pack
5.33851.0001 Glass bottle 10 mg
Description
OverviewA cell-permeable, bioactive, non-toxic naphthofurandione analog that blocks STAT3-driven gene transcription. Selectively diminishes gene expression and self-renewal in stemness high cancer cells. Shown to be more effective in stemness high cancer cell population (IC50 = 142 nM) compared to regular cancer cells (IC50 = 395 nM). Reduces spherogenesis in CD44 expressing cancer cells without affecting the colony formation in CD34+ hematopoietic stem cells. Effectively reduces the levels of Nanog, Axl, Sox-2, Klf4, survivin, c-Myc, Bmi-1, and β-catenin within a few hours following treatment. Displays broad spectrum activity against stemness high cancer cells from multiple tumors (IC50 = 291, 432, 624, 479, 549, and 729 nM for CAOV-3, SW-626, PaCa2, SNU-475, H1975, and U87-MG, respectively). Suppresses the growth of PaCa-2 xenografts in murine models that exhibited relapse of tumor growth (20 mg/kg, i.p, q.d.) following the cessation of 41-day gemcitabine treatment. Also shown to block cancer relapse, and spleen and liver metastasis in the intrasplenic nude mouse model injected with HT29 colon cancer cells.

Please note that the molecular weight for this compound is batch-specific due to variable water content. Please refer to the vial label or the certificate of analysis for the batch-specific molecular weight. The molecular weight provided represents the baseline molecular weight without water.
Catalogue Number533851
Brand Family Calbiochem®
Synonyms2-Acetyl-4H,9H-naphtho[2,3-b]furan-4,9-dione, 2-Acetylnaphtho[2,3-b]furan-4,9-dione, Spherogenesis Blocker, BBI-608
DescriptionCancer Stemness Inhibitor, BBI608
References
ReferencesLi, Y., et al. 2015. Proc. Natl. Acad. Sci. USA 112, 1839.
Product Information
CAS number83280-65-3
FormBrown solid
Hill FormulaC₁₄H₈O₄
Chemical formulaC₁₄H₈O₄
Quality LevelMQ100
Applications
Biological Information
Primary TargetSTAT3
Primary Target IC<sub>50</sub>142 nM
Purity≥97% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalog Number GTIN
5.33851.0001 04055977286762

Documentation

Cancer Stemness Inhibitor, BBI608 - CAS 83280-65-3 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

References

Reference overview
Li, Y., et al. 2015. Proc. Natl. Acad. Sci. USA 112, 1839.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision24-June-2016 JSW
Synonyms2-Acetyl-4H,9H-naphtho[2,3-b]furan-4,9-dione, 2-Acetylnaphtho[2,3-b]furan-4,9-dione, Spherogenesis Blocker, BBI-608
DescriptionA cell-permeable, bioactive, non-toxic naphthofurandione analog that blocks STAT3-driven gene transcription. Selectively diminishes gene expression and self-renewal in stemness high cancer cells. Shown to be more effective in stemness high cancer cell population (IC50 = 142 nM) compared to regular cancer cells (IC50 = 395 nM). Reduces spherogenesis in CD44 expressing cancer cells without affecting the colony formation in CD34+ hematopoietic stem cells. Effectively reduces the levels of Nanog, Axl, Sox-2, Klf4, survivin, c-Myc, Bmi-1, and β-catenin within a few hours following treatment. Displays broad spectrum activity against stemness high cancer cells from multiple tumors (IC50 = 291, 432, 624, 479, 549, and 729 nM for CAOV-3, SW-626, PaCa2, SNU-475, H1975, and U87-MG, respectively). Suppresses the growth of PaCa-2 xenografts in murine models that exhibited relapse of tumor growth (20 mg/kg, i.p, q.d.) following the cessation of 41-day gemcitabine treatment. Also shown to block cancer relapse, and spleen and liver metastasis in the intrasplenic nude mouse model injected with HT29 colon cancer cells.
FormBrown solid
Intert gas (Yes/No) Packaged under inert gas
CAS number83280-65-3
Chemical formulaC₁₄H₈O₄
Purity≥97% by HPLC
SolubilityDMSO (50 mg/ml)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesLi, Y., et al. 2015. Proc. Natl. Acad. Sci. USA 112, 1839.