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215911 Carbonyl Cyanide m-Chlorophenylhydrazone - CAS 555-60-2 - Calbiochem

Carbonyl Cyanide m-Chlorophenylhydrazone, CAS 555-60-2, is a protonophore uncoupling agent for oxidative phosphorylation. Shown to be about 100-fold more effective than 2, 4-DNP.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: CCCP

Primary Target: cytochrome c oxydase
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Overview

Replacement Information

Key Specifications Table

CAS #
555-60-2

Products

Catalog NumberPackaging Qty/Pack
215911-250MG Plastic ampoule 250 mg
Description
OverviewProtonophore. Uncoupling agent for oxidative phosphorylation that inhibits mitochondrial function. Approximately 100 times more effective than 2,4-dinitrophenol. Binds with cytochrome c oxidase with high affinity (Kd = 270 nM). Inhibits transport processes and depresses growth.
Catalogue Number215911
Brand Family Calbiochem®
SynonymsCCCP
References
ReferencesBona, M., et al. 1993. Gen. Physiol. Biophys. 12, 533.
Heytler, P.G., and Prichard, W.W. 1962. Biochem. Biophys. Res. Commun. 7, 272.
Product Information
CAS number555-60-2
ATP CompetitiveN
FormYellow solid
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
ApplicationCarbonyl Cyanide m-Chlorophenylhydrazone, CAS 555-60-2, is a protonophore uncoupling agent for oxidative phosphorylation. Shown to be about 100-fold more effective than 2, 4-DNP.
Biological Information
Primary Targetcytochrome c oxydase
Primary Target IC<sub>50</sub>Kd = 270 nM in binding with cytochrome c oxidase
Purity≥95% by HPLC
Physicochemical Information
Cell permeableN
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
RTECSFG5600000
Safety Information
R PhraseR: 20/21/22-36/37/38

Harmful by inhalation, in contact with skin and if swallowed.
Irritating to eyes, respiratory system and skin.
S PhraseS: 26-36

In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
Wear suitable protective clothing.
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Harmful
Storage +2°C to +8°C
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, store in the refrigerator (4°C). Stock solutions are stable for up to 1 month at 4°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalog Number GTIN
215911-250MG 04055977219241

Documentation

Carbonyl Cyanide m-Chlorophenylhydrazone - CAS 555-60-2 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

Carbonyl Cyanide m-Chlorophenylhydrazone - CAS 555-60-2 - Calbiochem Certificates of Analysis

TitleLot Number
215911

References

Reference overview
Bona, M., et al. 1993. Gen. Physiol. Biophys. 12, 533.
Heytler, P.G., and Prichard, W.W. 1962. Biochem. Biophys. Res. Commun. 7, 272.

Brochure

Title
Mitochondrial Metabolism Modulators
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision28-May-2008 RFH
SynonymsCCCP
DescriptionProtonophore. Uncoupling agent for oxidative phosphorylation that inhibits mitochondrial function. ~100 times more effective than 2,4-dinitrophenol. Binds cytochrome C oxidase with high affinity (Kd = 270 nM). Inhibits transport processes and depresses growth.
FormYellow solid
CAS number555-60-2
RTECSFG5600000
Structure formulaStructure formula
Purity≥95% by HPLC
SolubilityDMSO (5 mg/ml) or Etthanol (1 mg/ml)
Storage +2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, store in the refrigerator (4°C). Stock solutions are stable for up to 1 month at 4°C.
Toxicity Harmful
ReferencesBona, M., et al. 1993. Gen. Physiol. Biophys. 12, 533.
Heytler, P.G., and Prichard, W.W. 1962. Biochem. Biophys. Res. Commun. 7, 272.