218697 Sigma-AldrichCasein Kinase II Inhibitor I - CAS 17374-26-4 - Calbiochem
Casein Kinase II Inhibitor I, CAS 17374-26-4, is a cell-permeable, selective, reversible, and ATP/GTP-competitive inhibitor of casein kinase-2 (IC50 = 900 nM for rat liver CK2).
More>> Casein Kinase II Inhibitor I, CAS 17374-26-4, is a cell-permeable, selective, reversible, and ATP/GTP-competitive inhibitor of casein kinase-2 (IC50 = 900 nM for rat liver CK2). Less<<Synonyms: TBB, TBBt, 4,5,6,7-Tetrabromobenzotriazole, 4,5,6,7-Tetrabromo-2-azabenzimidazole, CK2 Inhibitor
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Overview
Key Specifications Table
CAS # | Empirical Formula |
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17374-26-4 | C₆HBr₄N₃ |
Products
Catalog Number | Packaging | Qty/Pack | |
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218697-10MG | Plastic ampoule | 10 mg |
Description | |
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Overview | A cell-permeable benzotriazolo compound that acts as a higly selective, reversible, and ATP/GTP-competitive inhibitor of casein kinase-2 (CK2) (IC50 = 900 nM and 1.6 µM, using rat liver and human recombinant CK2, respectively) and DYRK (IC50 < 1 µM for DYRK1a). Its specificity has been demonstrated using a panel of 33 kinases, including PKA, PKB, PKC, MKK1, Erk2, p38, JNK, Lck, Lyn, and Syk. Also shown to inhibit NS3-associated viral helicase activities in HCV (IC50 = 20 and 60 µM, using DNA and RNA substrate, respectively) and WNV (IC50 = 1.7 and 900 nM, using DNA and RNA substrate, respectively). A 10 mM (5 mg/1.15 ml) solution of Casein Kinase II Inhibitor I (Cat. No. 218708) in DMSO, is also available. |
Catalogue Number | 218697 |
Brand Family | Calbiochem® |
Synonyms | TBB, TBBt, 4,5,6,7-Tetrabromobenzotriazole, 4,5,6,7-Tetrabromo-2-azabenzimidazole, CK2 Inhibitor |
Product Information | |
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CAS number | 17374-26-4 |
ATP Competitive | Y |
Form | White solid |
Hill Formula | C₆HBr₄N₃ |
Chemical formula | C₆HBr₄N₃ |
Reversible | Y |
Structure formula Image | |
Quality Level | MQ100 |
Physicochemical Information | |
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Cell permeable | Y |
Packaging Information | |
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Packaged under inert gas | Packaged under inert gas |
Global Trade Item Number | |
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Catalog Number | GTIN |
218697-10MG | 04055977202502 |