Millipore Sigma Vibrant Logo
Attention: We have moved. EMD Millipore products are no longer available for purchase on emdmillipore.com.Learn More

218860 Casein Kinase II Inhibitor VIII - CAS 1361229-76-6 - Calbiochem

The Casein Kinase II Inhibitor VIII controls the biological activity of Casein Kinase II. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: CK2 Inhibitor VIII, DYRK1B Inhibitor, Flt-3 Inhibitor VII, 4-(2-(4-Methoxybenzamido)thiazol-5-yl)benzoic acid

Primary Target: CK2
View Products on Sigmaaldrich.com
218860
Purchase on Sigma-Aldrich

Overview

Replacement Information

Key Specifications Table

CAS #Empirical Formula
1361229-76-6C₁₈H₁₄N₂O₄S

Products

Catalog NumberPackaging Qty/Pack
218860-10MG Glass bottle 10 mg
Description
OverviewA cell-permeable thiazolamide compound that acts as a potent, reversible, and ATP-competitive inhibitor against casein kinase-2/CK2 (IC50 = 32 and 46 nM against CK2α and CK2α', respectively), as well as DYRK1B and FLt-3 (82% and 76% inhibition, respectively, at 30 nM), while diplaying reduced or little potency toward other targets in a 70-kinase panel selectivity profile study. Shown to effectively block the proliferation of a variety of cancer cells (IC50 = 2.6, 1.6, and 2.4 µM, in A549, HCT116, and MCF-7 cultures, respectively).
Catalogue Number218860
Brand Family Calbiochem®
SynonymsCK2 Inhibitor VIII, DYRK1B Inhibitor, Flt-3 Inhibitor VII, 4-(2-(4-Methoxybenzamido)thiazol-5-yl)benzoic acid
References
ReferencesHou, Z., et al. 2012. J. Med. Chem. 55, 2899.
Product Information
CAS number1361229-76-6
FormOff-white solid
Hill FormulaC₁₈H₁₄N₂O₄S
ReversibleY
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetCK2
Primary Target IC<sub>50</sub>32 and 46 nM for CK2&alpha
Secondary targetDYRK1B, Flt-3
Purity≥99% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalog Number GTIN
218860-10MG 04055977201963

Documentation

Casein Kinase II Inhibitor VIII - CAS 1361229-76-6 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

Casein Kinase II Inhibitor VIII - CAS 1361229-76-6 - Calbiochem Certificates of Analysis

TitleLot Number
218860

References

Reference overview
Hou, Z., et al. 2012. J. Med. Chem. 55, 2899.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision17-June-2013 JSW
SynonymsCK2 Inhibitor VIII, DYRK1B Inhibitor, Flt-3 Inhibitor VII, 4-(2-(4-Methoxybenzamido)thiazol-5-yl)benzoic acid
DescriptionA cell-permeable thiazolamide compound that acts as a potent, reversible, and ATP-competitive inhibitor against casein kinase-2/CK2 (IC50 = 32 and 46 nM against CK2α and CK2α', respectively), as well as DYRK1B and FLt-3 (82% and 76% inhibition, respectively, at 30 nM), while diplaying reduced or little potency toward other targets in a 70-kinase panel selectivity profile study. Shown to effectively block the proliferation of a variety of cancer cells (IC50 = 2.6, 1.6, and 2.4 µM, in A549, HCT116, and MCF-7 cultures, respectively).
FormOff-white solid
Intert gas (Yes/No) Packaged under inert gas
CAS number1361229-76-6
Structure formulaStructure formula
Purity≥99% by HPLC
SolubilityDMSO (50 mg/ml)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity Standard Handling
ReferencesHou, Z., et al. 2012. J. Med. Chem. 55, 2899.