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400011 Caspase-1 Inhibitor I, Cell-Permeable - Calbiochem

Caspase-1 Inhibitor I, Cell-Permeable, inhibits the activity of caspase-1 (Ki = 1 nM), 4 & 5. The N-terminal corresponds to the h-region of the signal peptide of K-FGF that confers cell-permeability.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: ICE Inhibitor I, Cell-permeable, YVAD-CHO, Cell-permeable, Ac-AAVALLPAVLLALLAPYVAD-CHO

Primary Target: Caspase-1
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400011
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Overview

Replacement Information

Key Specifications Table

Empirical Formula
C₉₇H₁₆₀N₂₀O₂₄

Products

Catalog NumberPackaging Qty/Pack
400011-1MG Plastic ampoule 1 mg
Description
OverviewA cell-permeable inhibitor of caspase-1 (ICE; Interleukin-1β Converting Enzyme), caspase-4, and caspase-5. The C-terminal YVAD-CHO sequence of this peptide is a highly specific, potent, and reversible inhibitor of caspase-1 (Ki = 1 nM). The N-terminal sequence (amino acid residues 1-16) corresponds to the hydrophobic region (h-region) of the signal peptide of the Kaposi fibroblast growth factor (K-FGF) and confers cell-permeability to the peptide.
Catalogue Number400011
Brand Family Calbiochem®
SynonymsICE Inhibitor I, Cell-permeable, YVAD-CHO, Cell-permeable, Ac-AAVALLPAVLLALLAPYVAD-CHO
References
ReferencesGarcia-Calvo, M., et al. 1998. J. Biol. Chem. 273, 32608.
Hilbi, H., et al. 1998. J. Biol. Chem. 273, 32895.
Thornberry, N.A., and Lazebnik, Y. 1998. Science 281, 1312.
Lin, Y.-Z., et al. 1996. J. Biol. Chem. 271, 5305.
Lin, Y.-Z., et al. 1995. J. Biol. Chem. 270, 14255.
Reiter, L.A. 1994. Int. J. Pept. Protein Res. 43, 87.
Thornberry, N.A., et al. 1994. Biochemistry 33, 3934.
Thornberry, N.A., et al. 1994. Methods Enzymol. 244, 615.
Thornberry, N.A., et al. 1992. Nature 356, 768.
Product Information
ATP CompetitiveN
FormWhite solid
Hill FormulaC₉₇H₁₆₀N₂₀O₂₄
Chemical formulaC₉₇H₁₆₀N₂₀O₂₄
ReversibleY
Quality LevelMQ100
Applications
ApplicationCaspase-1 Inhibitor I, Cell-Permeable, inhibits the activity of caspase-1 (Ki = 1 nM), 4 & 5. The N-terminal corresponds to the h-region of the signal peptide of K-FGF that confers cell-permeability.
Biological Information
Primary TargetCaspase-1
Primary Target K<sub>i</sub>1 nM
Purity≥97% by HPLC
Physicochemical Information
Cell permeableY
Peptide SequenceAc-Ala-Ala-Val-Ala-Leu-Leu-Pro-Ala-Val-Leu-Leu-Ala-Leu-Leu-Ala-Pro-Tyr-Val-Ala-Asp-CHO
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalog Number GTIN
400011-1MG 04055977212624

Documentation

Caspase-1 Inhibitor I, Cell-Permeable - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

Caspase-1 Inhibitor I, Cell-Permeable - Calbiochem Certificates of Analysis

TitleLot Number
400011

References

Reference overview
Garcia-Calvo, M., et al. 1998. J. Biol. Chem. 273, 32608.
Hilbi, H., et al. 1998. J. Biol. Chem. 273, 32895.
Thornberry, N.A., and Lazebnik, Y. 1998. Science 281, 1312.
Lin, Y.-Z., et al. 1996. J. Biol. Chem. 271, 5305.
Lin, Y.-Z., et al. 1995. J. Biol. Chem. 270, 14255.
Reiter, L.A. 1994. Int. J. Pept. Protein Res. 43, 87.
Thornberry, N.A., et al. 1994. Biochemistry 33, 3934.
Thornberry, N.A., et al. 1994. Methods Enzymol. 244, 615.
Thornberry, N.A., et al. 1992. Nature 356, 768.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision17-July-2014 JSW
SynonymsICE Inhibitor I, Cell-permeable, YVAD-CHO, Cell-permeable, Ac-AAVALLPAVLLALLAPYVAD-CHO
DescriptionA cell-permeable inhibitor of caspase-1 (ICE; interleukin-1β converting enzyme). The C-terminal YVAD-CHO sequence of this peptide is a highly specific, potent, and reversible inhibitor of caspase-1 (Ki = 1 nM). The N-terminal sequence (residues 1-16) corresponds to the hydrophobic region (h-region) of the signal peptide of Kaposi fibroblast growth factor (K-FGF) and confers cell-permeability to the peptide.
FormWhite solid
Chemical formulaC₉₇H₁₆₀N₂₀O₂₄
Peptide SequenceAc-Ala-Ala-Val-Ala-Leu-Leu-Pro-Ala-Val-Leu-Leu-Ala-Leu-Leu-Ala-Pro-Tyr-Val-Ala-Asp-CHO
Purity≥97% by HPLC
SolubilityDMSO (5 mg/ml)
Storage -20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
Toxicity Standard Handling
ReferencesGarcia-Calvo, M., et al. 1998. J. Biol. Chem. 273, 32608.
Hilbi, H., et al. 1998. J. Biol. Chem. 273, 32895.
Thornberry, N.A., and Lazebnik, Y. 1998. Science 281, 1312.
Lin, Y.-Z., et al. 1996. J. Biol. Chem. 271, 5305.
Lin, Y.-Z., et al. 1995. J. Biol. Chem. 270, 14255.
Reiter, L.A. 1994. Int. J. Pept. Protein Res. 43, 87.
Thornberry, N.A., et al. 1994. Biochemistry 33, 3934.
Thornberry, N.A., et al. 1994. Methods Enzymol. 244, 615.
Thornberry, N.A., et al. 1992. Nature 356, 768.