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219385 Cathepsin B Inhibitor II - Calbiochem

Overview

Replacement Information

Key Specifications Table

Empirical Formula
C₁₉H₃₆N₄O₄

Products

Catalog NumberPackaging Qty/Pack
219385-1MG Plastic ampoule 1 mg
Description
OverviewA more active lysinal analog of Leupeptin (Cat. No. 108975). A more potent inhibitor of cathepsin B (IC50 = 4 nM) compared to leupeptin (IC50 = 310 nM).
Note: this peptide forms cyclic isomers.
Catalogue Number219385
Brand Family Calbiochem®
SynonymsAc-LVK-CHO
References
ReferencesMcConnell, R.M., et al. 1993. J. Med. Chem. 36, 1084.
Product Information
ATP CompetitiveN
FormWhite solid
Hill FormulaC₁₉H₃₆N₄O₄
Chemical formulaC₁₉H₃₆N₄O₄
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary Targetcathepsin B
Primary Target IC<sub>50</sub>4 nM against cathepsin B
Purity≥95% by HPLC
Physicochemical Information
Cell permeableN
Peptide SequenceAc-Leu-Val-lysinal
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage ≤ -70°C
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution aliquot and freeze (-70°C). Stock solutions are stable for up to 1 month at -70°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalog Number GTIN
219385-1MG 04055977201666

Documentation

Cathepsin B Inhibitor II - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

Cathepsin B Inhibitor II - Calbiochem Certificates of Analysis

TitleLot Number
219385

References

Reference overview
McConnell, R.M., et al. 1993. J. Med. Chem. 36, 1084.

Brochure

Title
Cathepsins and Related Products Technical Bulletin

Citations

Title
  • Moin U Fareed, et al. (2006) Treatment of rats with calpain inhibitors prevents sepsis-induced muscle proteolysis independent of atrogin-1/MAFbx and MuRF1 expression. American Journal of Physiology Regulatory, Integrative and Comparative Physiology 290, R1589-R1597.
  • Data Sheet

    Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

    Revision03-October-2007 RFH
    SynonymsAc-LVK-CHO
    DescriptionLysinal analog of Leupeptin (Cat. No. 108975). A more potent inhibitor of cathepsin B (IC50 = 4 nM) than of leupeptin (IC50 = 310 nM). Note: this peptide forms cyclic isomers.
    FormWhite solid
    Chemical formulaC₁₉H₃₆N₄O₄
    Peptide SequenceAc-Leu-Val-lysinal
    Structure formulaStructure formula
    Purity≥95% by HPLC
    SolubilityH₂O (1 mg/ml)
    Storage ≤ -70°C
    Do Not Freeze Ok to freeze
    Special InstructionsFollowing reconstitution aliquot and freeze (-70°C). Stock solutions are stable for up to 1 month at -70°C.
    Toxicity Standard Handling
    ReferencesMcConnell, R.M., et al. 1993. J. Med. Chem. 36, 1084.
    Citation
  • Moin U Fareed, et al. (2006) Treatment of rats with calpain inhibitors prevents sepsis-induced muscle proteolysis independent of atrogin-1/MAFbx and MuRF1 expression. American Journal of Physiology Regulatory, Integrative and Comparative Physiology 290, R1589-R1597.