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217714 Cdk1/2 Inhibitor III - CAS 443798-55-8 - Calbiochem

The Cdk1/2 Inhibitor III, also referenced under CAS 443798-55-8, controls the biological activity of Cdk1/2. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 5-Amino-3-((4-(aminosulfonyl)phenyl)amino)-N-(2,6-difluorophenyl)-1H-1,2,4-triazole-1-carbothioamide

Primary Target: Cdk1/cyclin B, Cdk2/cyclin A
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Overview

Replacement Information

Key Specifications Table

CAS #Empirical Formula
443798-55-8C₁₅H₁₃F₂N₇O₂S₂

Products

Catalog NumberPackaging Qty/Pack
217714-1MG Plastic ampoule 1 mg
Description
OverviewA cell-permeable triazolo-diamine compound that displays anti-proliferative properties in various human cancer cells (IC50 = 20 nM, 35 nM and 92 nM in HCT-116, HeLa, and A375 cells, respectively). Acts as a highly potent, reversible, ATP-competitive inhibitor of Cdk1/cyclin B and Cdk2/cyclin A (IC50 = 600 pM and 500 pM, respectively) with selectivity over VEGF-R2 (IC50 = 32 nM), GSK-3β (IC50 = 140 nM), and a panel of eight other kinases (IC50 ≥ 1 µM).
Catalogue Number217714
Brand Family Calbiochem®
Synonyms5-Amino-3-((4-(aminosulfonyl)phenyl)amino)-N-(2,6-difluorophenyl)-1H-1,2,4-triazole-1-carbothioamide
References
ReferencesLin, R., et al. 2005.J. Med. Chem. 48, 4208.
Product Information
CAS number443798-55-8
ATP CompetitiveY
FormWhite solid
Hill FormulaC₁₅H₁₃F₂N₇O₂S₂
Chemical formulaC₁₅H₁₃F₂N₇O₂S₂
ReversibleY
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetCdk1/cyclin B, Cdk2/cyclin A
Primary Target IC<sub>50</sub>20 nM, 35 nM and 92 nM for anti-proliferative properties in HCT-116, HeLa, and A375 cells, respectively; 600 pM and 500 pM, against Cdk1/cyclin B and Cdk2/cyclin A, respectively
Purity≥95% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Harmful
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalog Number GTIN
217714-1MG 04055977202397

Documentation

Cdk1/2 Inhibitor III - CAS 443798-55-8 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

Cdk1/2 Inhibitor III - CAS 443798-55-8 - Calbiochem Certificates of Analysis

TitleLot Number
217714

References

Reference overview
Lin, R., et al. 2005.J. Med. Chem. 48, 4208.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision16-December-2009 RFH
Synonyms5-Amino-3-((4-(aminosulfonyl)phenyl)amino)-N-(2,6-difluorophenyl)-1H-1,2,4-triazole-1-carbothioamide
DescriptionA cell-permeable triazolo-diamine compound that displays anti-proliferative properties in various human cancer cells (IC50 = 20 nM, 35 nM and 92 nM in HCT-116, HeLa, and A375 cells, respectively). Acts as a highly potent, reversible, ATP-competitive inhibitor of Cdk1/cyclin B and Cdk2/cyclin A (IC50 = 600 pM and 500 pM, respectively) with selectivity over VEGF-R2 (IC50 = 32 nM), GSK-3β (IC50 = 140 nM), and a panel of eight other kinases (IC50 ≥ 1 µM).
FormWhite solid
Intert gas (Yes/No) Packaged under inert gas
CAS number443798-55-8
Chemical formulaC₁₅H₁₃F₂N₇O₂S₂
Structure formulaStructure formula
Purity≥95% by HPLC
SolubilityDMSO (10 mg/ml), Acetone or THF
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity Harmful
ReferencesLin, R., et al. 2005.J. Med. Chem. 48, 4208.