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219465 Celastrol, Celastrus scandens - CAS 34157-83-0 - Calbiochem

A cell-permeable dienone-phenolic triterpene compound that exhibits antioxidant and anti-inflammatory properties.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Tripterin, 3-Hydroxy-24-nor-2-oxo-1(10),3,5,7-friedelatetraen-29-oic Acid, Proteasome Inhibitor XIX

Primary Target: 20S proteasome
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Overview

Replacement Information

Key Specifications Table

CAS #Empirical Formula
34157-83-0C₂₉H₃₈O₄

Products

Catalog NumberPackaging Qty/Pack
219465-10MG Plastic ampoule 10 mg
Description
OverviewA cell-permeable dienone-phenolic triterpene compound that exhibits antioxidant and anti-inflammatory properties. It suppresses LPS-induced pro-inflammatory cytokines release in macrophages and monocytes (IC50 = 40 nM for IL-1β and IL-1α, 80 nM for IL-6, 110 nM for PGE2, and 210 nM for IL-8 and TNF-α), as well as LPS-induced NF-κB activation (IC50 = 270 nM) and NO production (IC50 = 230 nM) in RAW264.7 cells. Preferentially inhibits chymotrypsin-like activity of 20S proteasome with an IC50 of 2.5 µM. Has also been shown to inhibit lipid peroxidation induced by ADP and Fe2+ in rat liver mitochondria (IC50 = 7 µM). Significantly improves the performance in memory, learning, and psychomotor activity in rats. May be useful to minimize inflammation in Alzheimer′s disease (AD).
Catalogue Number219465
Brand Family Calbiochem®
SynonymsTripterin, 3-Hydroxy-24-nor-2-oxo-1(10),3,5,7-friedelatetraen-29-oic Acid, Proteasome Inhibitor XIX
References
ReferencesYang, H., et al. 2006. Cancer Res. 66, 4758.
Westerheide, S.D., et al. 2004. J. Biol. Chem. 279, 56053.
Jin, H.Z., et al. 2002. J. Nat. Prod. 65, 89.
Allison, A.C., et al. 2001. Prog. Neuropsychopharmacol. Biol. Psychiatry 25, 1341.
He, W., et al. 1998. Bioorg. Med. Chem. Lett. 8, 3659.
Sassa, H., et al. 1990. Biochem. Biophys. Res. Commun. 172, 890.
Product Information
CAS number34157-83-0
ATP CompetitiveN
FormRed crystals
Hill FormulaC₂₉H₃₈O₄
Chemical formulaC₂₉H₃₈O₄
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary Target20S proteasome
Primary Target IC<sub>50</sub>2.5 µM inhibiting chymotrypsin-like activity of 20S proteasome
Purity≥95% by TLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalog Number GTIN
219465-10MG 04055977218459

Documentation

Celastrol, Celastrus scandens - CAS 34157-83-0 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

Celastrol, Celastrus scandens - CAS 34157-83-0 - Calbiochem Certificates of Analysis

TitleLot Number
219465

References

Reference overview
Yang, H., et al. 2006. Cancer Res. 66, 4758.
Westerheide, S.D., et al. 2004. J. Biol. Chem. 279, 56053.
Jin, H.Z., et al. 2002. J. Nat. Prod. 65, 89.
Allison, A.C., et al. 2001. Prog. Neuropsychopharmacol. Biol. Psychiatry 25, 1341.
He, W., et al. 1998. Bioorg. Med. Chem. Lett. 8, 3659.
Sassa, H., et al. 1990. Biochem. Biophys. Res. Commun. 172, 890.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision05-June-2008 RFH
SynonymsTripterin, 3-Hydroxy-24-nor-2-oxo-1(10),3,5,7-friedelatetraen-29-oic Acid, Proteasome Inhibitor XIX
DescriptionA cell-permeable dienone-phenolic triterpene compound with antioxidant and anti-inflammatory properties. It suppresses LPS-induced release of pro-inflammatory cytokines in macrophages and monocytes (IC50 = 40 nM for IL-1β and IL-1α, 80 nM for IL-6, 110 nM for PEG2, and 210 nM for IL-8 and TNF-α). Also suppresses LPS-induced NF-κB activation (IC50 = 270 nM) and NO production (IC50 = 230 nM) in RAW264.7 cells. Preferentially inhibits chymotrypsin-like activity of 20S proteasome with an IC50 of 2.5 µM. Shown to inhibit lipid peroxidation induced by ADP and Fe2+ in rat liver mitochondria (IC50 = 7 µM). Improves performance in memory, learning, and psychomotor activity in rats. May be useful in minimizing inflammation in Alzheimer's disease animal models.
FormRed crystals
Intert gas (Yes/No) Packaged under inert gas
CAS number34157-83-0
Chemical formulaC₂₉H₃₈O₄
Structure formulaStructure formula
Purity≥95% by TLC
SolubilityDMSO (5 mg/ml) or Ethanol
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesYang, H., et al. 2006. Cancer Res. 66, 4758.
Westerheide, S.D., et al. 2004. J. Biol. Chem. 279, 56053.
Jin, H.Z., et al. 2002. J. Nat. Prod. 65, 89.
Allison, A.C., et al. 2001. Prog. Neuropsychopharmacol. Biol. Psychiatry 25, 1341.
He, W., et al. 1998. Bioorg. Med. Chem. Lett. 8, 3659.
Sassa, H., et al. 1990. Biochem. Biophys. Res. Commun. 172, 890.