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232120 Cisplatin - CAS 15663-27-1 - Calbiochem

Cisplatin - CAS 15663-27-1, is a platinum coordination complex with potent anti-neoplastic activity. Induces apoptosis in cancer cells, possibly via caspase-3 activation.

Cisplatin - CAS 15663-27-1 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: CPDC, DDP, cis-Diaminedichloroplatinum

Primary Target: Induces apoptosis in cancer cells
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232120
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Overview

Replacement Information

Key Specifications Table

CAS #Empirical Formula
15663-27-1Pt(NH₃)₂Cl₂

Products

Catalog NumberPackaging Qty/Pack
232120-50MG Glass bottle 50 mg
Description
OverviewA platinum coordination complex with potent anti-neoplastic activity. Induces apoptosis in cancer cells, possibly via caspase-3 activation. Reported to sensitize glioma cells to TNF-α-induced apoptosis.

Note: Athough highly soluble in DMSO, Cisplatin is reported to be rendered inactive due to ligand displacement by the nucleophilic sulfur of DMSO. Sodium chloride solution in water (154 mM NaCl with or without 10 mg/ml mannitol) or PBS (with 140 mM NaCl) is recommended for solubilization prior to culture treatment.
Catalogue Number232120
Brand Family Calbiochem®
SynonymsCPDC, DDP, cis-Diaminedichloroplatinum
References
ReferencesHall, M.D., et al. 2014. Cancer Res. In press.
Duan, L., et al. 2001. J. Neurooncol. 52, 23.
Mese, H., et al. 2000. Cancer Chemother. Pharmacol. 46, 241.
Von Hoff, D.D., and Rozencweig, M. 1979. in Adv. Pharmacol. Chemother. 16, 279.
Product Information
CAS number15663-27-1
ATP CompetitiveN
FormYellow solid
Hill FormulaPt(NH₃)₂Cl₂
Chemical formulaPt(NH₃)₂Cl₂
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetInduces apoptosis in cancer cells
Purity≥98% by HPLC
Physicochemical Information
Cell permeableN
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
RTECSTP2450000
Safety Information
R PhraseR: 25-36/37/38-45-42/43

Toxic if swallowed.
Irritating to eyes, respiratory system and skin.
May cause cancer.
May cause sensitization by inhalation and skin contact.
S PhraseS: 22-24-37-45-53

Do not breathe dust.
Avoid contact with skin.
Wear suitable gloves.
In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
Avoid exposure - obtain special instructions before use.
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Toxic & Carcinogenic / Teratogenic
Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
Storage +2°C to +8°C
Do not freeze Ok to freeze
Special InstructionsUnstable in solution; reconstitute just prior to use.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalog Number GTIN
232120-50MG 04055977217605

Documentation

Cisplatin - CAS 15663-27-1 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

Cisplatin - CAS 15663-27-1 - Calbiochem Certificates of Analysis

TitleLot Number
232120

References

Reference overview
Hall, M.D., et al. 2014. Cancer Res. In press.
Duan, L., et al. 2001. J. Neurooncol. 52, 23.
Mese, H., et al. 2000. Cancer Chemother. Pharmacol. 46, 241.
Von Hoff, D.D., and Rozencweig, M. 1979. in Adv. Pharmacol. Chemother. 16, 279.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision08-July-2014 JSW
SynonymsCPDC, DDP, cis-Diaminedichloroplatinum
DescriptionA platinum coordination complex with potent antineoplastic activity.

Note: Athough highly soluble in DMSO, Cisplatin is reported to be rendered inactive due to ligand displacement by the nucleophilic sulfur of DMSO. Sodium chloride solution in water (154 mM NaCl with or without 10 mg/ml mannitol) or PBS (with 140 mM NaCl) is recommended for solubilization prior to culture treatment.
FormYellow solid
CAS number15663-27-1
RTECSTP2450000
Chemical formulaPt(NH₃)₂Cl₂
Structure formulaStructure formula
Purity≥98% by HPLC
SolubilityDMSO (10 mg/ml), H₂O with 154 mM NaCl (1 mg/ml), or PBS with 140 mM NaCl (1 mg/ml)
Storage +2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsUnstable in solution; reconstitute just prior to use.
Toxicity Toxic & Carcinogenic / Teratogenic
Merck USA index14, 2317
ReferencesHall, M.D., et al. 2014. Cancer Res. In press.
Duan, L., et al. 2001. J. Neurooncol. 52, 23.
Mese, H., et al. 2000. Cancer Chemother. Pharmacol. 46, 241.
Von Hoff, D.D., and Rozencweig, M. 1979. in Adv. Pharmacol. Chemother. 16, 279.