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500112 Cocarboxylase chloride

(thiamine diphosphoric acid ester chloride) EMPROVE® API

Cocarboxylase chloride MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Thiaminium diphosphoric acid ester chloride, Thiaminium pyrophosphate chloride, Thiaminium pyrophosphoric acid ester chloride, TPP

CAS #: 154-87-0 EC Number: 205-836-1 Molar Mass: 460.80 g/mol Hill Formula: C₁₂H₁₉ClN₄O₇P₂S
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Overview

Replacement Information

Key Specifications Table

CAS #EC NumberHill FormulaMolar Mass
154-87-0205-836-1C₁₂H₁₉ClN₄O₇P₂S460.80 g/mol

Products

Catalog NumberPackaging Qty/Pack
5001120100 Plastic bottle 100 g
5001121000 Plastic bottle 1 kg
5001125000 Plastic bottle 5 kg
Description
Catalogue Number500112
SynonymsThiaminium diphosphoric acid ester chloride, Thiaminium pyrophosphate chloride, Thiaminium pyrophosphoric acid ester chloride, TPP
References
Product Information
CAS number154-87-0
EC number205-836-1
Hill FormulaC₁₂H₁₉ClN₄O₇P₂S
Molar Mass460.80 g/mol
HS Code2936 22 90
Structure formula ImageStructure formula Image
Quality LevelMQ600
Applications
Biological Information
Physicochemical Information
Melting Point240 - 244 °C (decomposition)
pH value2.2 (H₂O)
Bulk density500 kg/m3
Solubility220 g/l
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Hazard Pictogram(s) Hazard Pictogram(s)
Hazard Statement(s)H317: May cause an allergic skin reaction.
Precautionary Statement(s)P261: Avoid breathing dust.
P272: Contaminated work clothing should not be allowed out of the workplace.
P280: Wear protective gloves.
P302 + P352: IF ON SKIN: Wash with plenty of water.
P333 + P313: If skin irritation or rash occurs: Get medical advice/ attention.
P362 + P364: Take off contaminated clothing and wash it before reuse.
Signal WordWarning
RTECSXI7552000
Storage class10 - 13 Other liquids and solids
WGKWGK 1 slightly hazardous to water
Safety Information
Product Usage Statements
Storage and Shipping Information
StorageStore at +2°C to +25°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Assay (HPLC, calc. on dried substance)≥ 93.0 %
Appearance (color)white
Appearance (description)crystalline powder
Identity (IR-spectrum)conforms
Identity (Cl)passes test
Appearance of solution (10 %; water)clear,< colour reference solution Y7
pH-value (10 %; water)1.0 - 1.4
Chloride (Cl) (calculated on dried substance)7.5 - 7.9 %
Free phosphate (PO₄)≤ 1.0 %
Sulfate (SO₄)≤ 0.01 %
Al (Aluminium) (#)≤ 0.0010 %
As (Arsenic)≤ 0.0003 %
Ni (Nickel) (#)≤ 0.0002 %
Thiamin Monophosphoric Acid Ester Chloride (HPLC)≤ 4.0 %
Thiamin Dichloride (HPLC)≤ 0.5 %
Dithiamine Triphosphate (HPLC)≤ 0.20 %
Impurity A (HPLC)≤ 0.1
Impurity B (HPLC)≤ 0.1
Related substances (HPLC)≤ 1.5 %
Loss on drying (130 °C)≤ 1.5 %
Endotoxins≤ 12 I.U./g
Microbiological testpasses test
Colony count (aerobic bacteria (TAMC))≤ 500 CFU/g
Colony count (Yeasts and moulds (TYMC))≤ 100 CFU/g
Salmonella speciesIn 10g substance not detectable
E.coliIn 1g substance not detectable
Staphylococcus aureusIn 1g substance not detectable
Pseudomonas aeruginosaIn 1g substance not detectable
Candida albicansIn 1g substance not detectable
Residual solvents (Ph Eur/USP/ICH) class 2 (Methanol)≤ 2.0 %
Other residual solvents (Ph Eur/USP/ICH)excluded by manufacturing process
Elemental impurity specifications have been set considering ICH Q3D (Guideline for Elemental Impurities).
Class 1-3 elements are not likely to be present above the ICH Q3D option 1 limit, unless specified and indicated (#).
Residues of metal or metal reagents acc. to EMEA/CHMP/SWP/ 4446/2000 are not likely to be present.
Global Trade Item Number
Catalog Number GTIN
5001120100 04027269564223
5001121000 04022536255934
5001125000 04022536255972

Documentation

Emprove® API Information Package

Title

Cocarboxylase chloride SDS

Title

Safety Data Sheet (SDS) 

Cocarboxylase chloride Certificates of Analysis

Product Number PackagingSpecificationLot Number
5001120100 Plastic bottlePDF Specification Document
5001121000 Plastic bottlePDF Specification Document
5001125000 Plastic bottlePDF Specification Document

Certificates

Title

Brochure

Title
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