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182015 Cyclo(Arg-Gly-Asp-D-Phe-Val) - CAS 137813-35-5 - Calbiochem

Potent inhibitor of cell adhesion.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: RGDFV Peptide, Cyclic

Primary Target: inhibits tumor cell adhesion to laminin and vitronectin substrates
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182015
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Overview

Replacement Information

Key Specifications Table

CAS #Empirical Formula
137813-35-5C₂₆H₃₈N₈O₇

Products

Catalog NumberPackaging Qty/Pack
182015-1MG Plastic ampoule 1 mg
Description
OverviewPotent inhibitor of cell adhesion. Inhibits tumor cell adhesion to laminin and vitronectin substrates. In vivo investigations in rats showed it to be useful in the amelioration of ischemic acute renal failure in rats. Also inhibits tubular obstruction by preventing cell-cell adhesion. Inhibits the redistribution of c-Src into focal adhesions, thereby leading to impaired MAP Kinase activation.
Catalogue Number182015
Brand Family Calbiochem®
SynonymsRGDFV Peptide, Cyclic
References
ReferencesShono, T., et al. 2001. Exp. Cell Res. 268, 169.
Matsuno, H., et al. 1994. Circulation 90, 2203.
Noiri, E., et al. 1994. Kidney Int. 46, 1050.
Gurrath, M., et al. 1992. Eur. J. Biochem. 210, 911.
Product Information
CAS number137813-35-5
ATP CompetitiveN
FormWhite solid
FormulationSupplied as a trifluoroacetate salt
Hill FormulaC₂₆H₃₈N₈O₇
Chemical formulaC₂₆H₃₈N₈O₇
Hygroscopic Hygroscopic
ReversibleN
Quality LevelMQ100
Applications
Biological Information
Primary Targetinhibits tumor cell adhesion to laminin and vitronectin substrates
Purity≥95% by HPLC
Physicochemical Information
Cell permeableN
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalog Number GTIN
182015-1MG 04055977205039

Documentation

Cyclo(Arg-Gly-Asp-D-Phe-Val) - CAS 137813-35-5 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

Cyclo(Arg-Gly-Asp-D-Phe-Val) - CAS 137813-35-5 - Calbiochem Certificates of Analysis

TitleLot Number
182015

References

Reference overview
Shono, T., et al. 2001. Exp. Cell Res. 268, 169.
Matsuno, H., et al. 1994. Circulation 90, 2203.
Noiri, E., et al. 1994. Kidney Int. 46, 1050.
Gurrath, M., et al. 1992. Eur. J. Biochem. 210, 911.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision15-April-2008 RFH
SynonymsRGDFV Peptide, Cyclic
DescriptionPotent inhibitor of cell adhesion. Inhibits tumor cell adhesion to laminin and vitronectin substrates. In vivo investigations showed it to be useful in the amelioration of ischemic acute renal failure in rats. Also inhibits tubular obstruction by preventing cell-cell adhesion.
FormWhite solid
FormulationSupplied as a trifluoroacetate salt
CAS number137813-35-5
Chemical formulaC₂₆H₃₈N₈O₇
Purity≥95% by HPLC
Solubility1 N Acetic acid (5 mg/ml)
Storage -20°C
Hygroscopic
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
Toxicity Standard Handling
ReferencesShono, T., et al. 2001. Exp. Cell Res. 268, 169.
Matsuno, H., et al. 1994. Circulation 90, 2203.
Noiri, E., et al. 1994. Kidney Int. 46, 1050.
Gurrath, M., et al. 1992. Eur. J. Biochem. 210, 911.