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567726 D-erythro-Sphingosine, Free Base, High Purity - CAS 123-78-4 - Calbiochem

Highly purified preparation of bovine brain sphingosine containing >99% of the erythro isomer.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Cerebroside, trans-D-erythro-2-Amino-4-octadecene-1,3-diol, Ceramide

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567726
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Overview

Replacement Information

Key Specifications Table

CAS #Empirical Formula
123-78-4C₁₈H₃₇NO₂

Products

Catalog NumberPackaging Qty/Pack
567726-10MG Plastic ampoule 10 mg
Description
OverviewHighly purified preparation of bovine brain sphingosine containing >99% of the erythro isomer.
Catalogue Number567726
Brand Family Calbiochem®
SynonymsCerebroside, trans-D-erythro-2-Amino-4-octadecene-1,3-diol, Ceramide
References
Product Information
CAS number123-78-4
ATP CompetitiveN
FormWhite solid
Hill FormulaC₁₈H₃₇NO₂
Chemical formulaC₁₈H₃₇NO₂
ReversibleN
Quality LevelMQ100
Applications
Biological Information
Primary TargetPKC
Primary Target IC<sub>50</sub>2.8 µM against PKC
Purity≥98% by TLC
Physicochemical Information
Cell permeableN
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
R PhraseR: 36/37/38

Irritating to eyes, respiratory system and skin.
S PhraseS: 26-36

In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
Wear suitable protective clothing.
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Irritant
Storage -20°C
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot, purge with N₂ gas, and freeze (-20°C). Stock solutions are stable for up to 6 months under inert atmosphere at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalog Number GTIN
567726-10MG 04055977190830

Documentation

D-erythro-Sphingosine, Free Base, High Purity - CAS 123-78-4 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

D-erythro-Sphingosine, Free Base, High Purity - CAS 123-78-4 - Calbiochem Certificates of Analysis

TitleLot Number
567726

Brochure

Title
Bioactive Lipids Technical Bulletin
PKC Pathway Poster PDF ( 676 KB )
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision11-January-2010 RFH
SynonymsCerebroside, trans-D-erythro-2-Amino-4-octadecene-1,3-diol, Ceramide
DescriptionHighly purified preparation of bovine brain sphingosine containing >99% of the erythro isomer. A potent, cell-permeable, reversible, and selective inhibitor of protein kinase C (PKC; IC50 = 2.8 µM) and insulin receptor tyrosine kinase. PKC inhibition is competitive with respect to diacylglycerol, phorbol dibutyrate, and Ca2+. Does not affect the activity of myosin light chain kinase and protein kinase A. Induces apoptosis in human leukemia HL-60 cells. Note: This product is not to be used for animal treatment, in vivo research or in any other contact procedure with livestock.
FormWhite solid
CAS number123-78-4
Chemical formulaC₁₈H₃₇NO₂
Purity≥98% by TLC
SolubilityMethanol (1 mg/ml), Chloroform (1 mg/ml), or DMSO (10 mg/ml)
Storage -20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot, purge with N₂ gas, and freeze (-20°C). Stock solutions are stable for up to 6 months under inert atmosphere at -20°C.
Toxicity Irritant
Merck USA index14, 8747