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251650 Damnacanthal - CAS 477-84-9 - Calbiochem

A cell-permeable, potent, reversible, and selective inhibitor of p56lck tyrosine kinase.

Damnacanthal - CAS 477-84-9 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 3-Hydroxy-1-methoxyanthraquinone-2-aldehyde

Primary Target: p56lck autophosphorylation
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Overview

Replacement Information

Key Specifications Table

CAS #Empirical Formula
477-84-9C₁₆H₁₀O₅

Products

Catalog NumberPackaging Qty/Pack
251650-1MG Plastic ampoule 1 mg
Description
OverviewA cell-permeable, potent, reversible, and selective inhibitor of p56lck tyrosine kinase. Inhibits p56lck autophosphorylation (IC50 = 17 nM) and phosphorylation of an exogenous peptide by p56lck (IC50 = 620 nM). Exhibits over 100-fold greater selectivity for p56lck over PKA and PKC, 40-fold greater selectivity for p56lck over EGF receptor kinase, c-ErbB2, insulin receptor kinase, and PDGF receptor kinase, and 7 - 20-fold greater selectivity for p56lck over p60src and p59fyn. Inhibition of p56lck is not significantly affected by the presence of sulfhydryl reagents. Also known to have antimalarial properties and to reverse the phenotype of ras-transformed cells.
Catalogue Number251650
Brand Family Calbiochem®
Synonyms3-Hydroxy-1-methoxyanthraquinone-2-aldehyde
References
ReferencesFaltynek, C.R., et al. 1995. Biochemistry 34, 12404.
Hiramatsu, T., et al. 1993. Cancer Lett. 73, 161.
Koumaglo, K., et al. 1992. Planta Med. 58, 533.
Product Information
CAS number477-84-9
ATP CompetitiveN
FormOrange-yellow solid
Hill FormulaC₁₆H₁₀O₅
Chemical formulaC₁₆H₁₀O₅
ReversibleY
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary Targetp56lck autophosphorylation
Primary Target IC<sub>50</sub>17 nM against p56lck autophosphorylation
Purity≥95% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalog Number GTIN
251650-1MG 04055977198553

Documentation

Damnacanthal - CAS 477-84-9 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

Damnacanthal - CAS 477-84-9 - Calbiochem Certificates of Analysis

TitleLot Number
251650

References

Reference overview
Faltynek, C.R., et al. 1995. Biochemistry 34, 12404.
Hiramatsu, T., et al. 1993. Cancer Lett. 73, 161.
Koumaglo, K., et al. 1992. Planta Med. 58, 533.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision21-April-2011 JSW
Synonyms3-Hydroxy-1-methoxyanthraquinone-2-aldehyde
DescriptionA cell-permeable, potent, reversible, and selective inhibitor of p56lck tyrosine kinase activity. Inhibits p56lck autophosphorylation (IC50 = 17 nM) and phosphorylation of an exogenous peptide by p56lck over PKA and PKC and >40 fold selectivity for p56lck over EGF, c-erbB2, insulin, and the PDGF receptor tyrosine kinases. In addition, damnacanthal exhibits 7-20 fold selectivity for p56lck over pp60src and pp59fyn. Inhibition of p56lck by damnacanthal appears to be reversible, not time-dependent and not significantly affected by the presence of sulfhydryl reagents. Also known to have antimalarial properties, and to reverse the phenotype of ras-transformed cells.
FormOrange-yellow solid
Intert gas (Yes/No) Packaged under inert gas
CAS number477-84-9
Chemical formulaC₁₆H₁₀O₅
Structure formulaStructure formula
Purity≥95% by HPLC
SolubilityDMSO (5 mg/ml)
Storage Protect from light
-20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
Toxicity Standard Handling
ReferencesFaltynek, C.R., et al. 1995. Biochemistry 34, 12404.
Hiramatsu, T., et al. 1993. Cancer Lett. 73, 161.
Koumaglo, K., et al. 1992. Planta Med. 58, 533.