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298711 Diethyl Pyrocarbonate - CAS 1609-47-8 - Calbiochem

Inhibits ryanodine binding to ryanodine/Ca2+ receptor channel in skeletal muscle in a dose- and time-dependent manner and increases the Ca2+ permeability of SR vesicles.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Diethyl Oxydiformate, DEPC

Primary Target: Inhibits ryanodine binding to ryanodine/Ca2+ receptor channel in skeletal muscle
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Overview

Replacement Information

Key Specifications Table

CAS #Empirical Formula
1609-47-8C₆H₁₀O₅

Products

Catalog NumberPackaging Qty/Pack
298711-100GM Glass bottle 100 gm
298711-25GM Plastic ampoule 25 gm
Description
OverviewInhibits ryanodine binding to ryanodine/Ca2+ receptor channel in skeletal muscle in a dose- and time-dependent manner and increases the Ca2+ permeability of SR vesicles. Useful for specific inactivation of nucleases during isolation of undegraded polynucleotides. Also inhibits platelet-activating factor acetyl hydrolase. Has been used as a probe for the topography of 5.8S rRNA in yeast ribosomes.
Catalogue Number298711
Brand Family Calbiochem®
SynonymsDiethyl Oxydiformate, DEPC
References
ReferencesShoshan-Barmatz, V., and Weil, S. 1994. Biochem. J. 299, 177.
Blumbers, D.O. 1987. Methods Enzymol. 152, 20.
Product Information
CAS number1609-47-8
ATP CompetitiveN
FormClear colorless liquid
Hill FormulaC₆H₁₀O₅
Chemical formulaC₆H₁₀O₅
ReversibleN
Quality LevelMQ100
Applications
Biological Information
Primary TargetInhibits ryanodine binding to ryanodine/Ca2+ receptor channel in skeletal muscle
Purity≥96% by titration
Physicochemical Information
Cell permeableN
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
RTECSLQ9350000
Safety Information
R PhraseR: 22-36/37/38

Harmful if swallowed.
Irritating to eyes, respiratory system and skin.
S PhraseS: 26-36

In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
Wear suitable protective clothing.
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Harmful
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalog Number GTIN
298711-100GM 04055977197952
298711-25GM 07790788049041

Documentation

Diethyl Pyrocarbonate - CAS 1609-47-8 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

Diethyl Pyrocarbonate - CAS 1609-47-8 - Calbiochem Certificates of Analysis

TitleLot Number
298711

References

Reference overview
Shoshan-Barmatz, V., and Weil, S. 1994. Biochem. J. 299, 177.
Blumbers, D.O. 1987. Methods Enzymol. 152, 20.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision08-October-2019 JSW
SynonymsDiethyl Oxydiformate, DEPC
DescriptionInhibits ryanodine binding to ryanodine/Ca2+ receptor channel in skeletal muscle. Useful for specific inactivation of nucleases during isolation of undegraded polynucleotides. Also inhibits platelet-activating factor acetyl hydrolase. Has been used as a probe for the topography of 5.8S rRNA in yeast ribosomes.
FormClear colorless liquid
CAS number1609-47-8
RTECSLQ9350000
Chemical formulaC₆H₁₀O₅
Purity≥96% by titration
SolubilityChloroform or Ethanol
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Toxicity Harmful
Merck USA index14, 7998
ReferencesShoshan-Barmatz, V., and Weil, S. 1994. Biochem. J. 299, 177.
Blumbers, D.O. 1987. Methods Enzymol. 152, 20.