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322338 Dvl-PDZ Domain Inhibitor II - CAS 294891-81-9 - Calbiochem

The Dvl-PDZ Domain Inhibitor II, also referenced under CAS 294891-81-9, controls the biological activity of Dvl-PDZ. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Wnt Pathway Inhibitor IV, 2-((3-(2-Phenylacetyl)amino)benzoyl)amino)benzoic acid, 3289-8625

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Overview

Replacement Information

Key Specifications Table

CAS #Empirical Formula
294891-81-9C₂₂H₁₈N₂O₄

Products

Catalog NumberPackaging Qty/Pack
322338-10MG Glass bottle 10 mg
Description
OverviewA cell-permeable amidobenzanilide compound that disrupts Fz-Dvl (frizzled-dishevelled) interaction by targeting the PDZ domain (Kd = 10.6 µM) of Dvl, blocking Wnt3a-induced (10 ng/ml) transcription activity (~50% inhibition at 3 µM in 293 cell SuperTopflash reporter assays) and suppressing the Wnt pathway-dependent growth of prostate cancer PC-3 cells (by 16% in 72 h at ≥50 µM; IC50 = 12.5 µM). Shown to effectively prevent Wnt3A mRNA injection-induced xenopus embryo deformation (effective conc. = 25 µM) and suppress Wnt pathway-mediated apoptosis of the hyaloid vescular endothelial cells in the mouse eyes via vitreous injection (144 fmol/120 nl/eye) in vivo.
Catalogue Number322338
Brand Family Calbiochem®
SynonymsWnt Pathway Inhibitor IV, 2-((3-(2-Phenylacetyl)amino)benzoyl)amino)benzoic acid, 3289-8625
References
ReferencesGrandy, D., et al. 2009. J. Biol. Chem. 284, 16256.
Product Information
CAS number294891-81-9
FormWhite solid
Hill FormulaC₂₂H₁₈N₂O₄
Chemical formulaC₂₂H₁₈N₂O₄
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Purity≥95% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalog Number GTIN
322338-10MG 04055977216356

Documentation

Dvl-PDZ Domain Inhibitor II - CAS 294891-81-9 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

Dvl-PDZ Domain Inhibitor II - CAS 294891-81-9 - Calbiochem Certificates of Analysis

TitleLot Number
322338

References

Reference overview
Grandy, D., et al. 2009. J. Biol. Chem. 284, 16256.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision07-April-2011 RFH
SynonymsWnt Pathway Inhibitor IV, 2-((3-(2-Phenylacetyl)amino)benzoyl)amino)benzoic acid, 3289-8625
DescriptionA cell-permeable amidobenzanilide compound that disrupts Fz-Dvl (frizzled-dishevelled) interaction by targeting the PDZ domain (Kd = 10.6 µM) of Dvl, blocking Wnt3a-induced (10 ng/ml) transcription activity (~50% inhibition at 3 µM in 293 cell SuperTopflash reporter assays) and suppressing the Wnt pathway-dependent growth of prostate cancer PC-3 cells (by 16% in 72 h at ≥50 µM; IC50 = 12.5 µM). Shown to effectively prevent Wnt3A mRNA injection-induced xenopus embryo deformation (effective conc. = 25 µM) and suppress Wnt pathway-mediated apoptosis of the hyaloid vescular endothelial cells in the mouse eyes via vitreous injection (144 fmol/120 nl/eye) in vivo.
FormWhite solid
Intert gas (Yes/No) Packaged under inert gas
CAS number294891-81-9
Chemical formulaC₂₂H₁₈N₂O₄
Structure formulaStructure formula
Purity≥95% by HPLC
SolubilityDMSO (50 mg/ml)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity Standard Handling
ReferencesGrandy, D., et al. 2009. J. Biol. Chem. 284, 16256.