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324414 Dynamin Inhibitor V, 34-2 - CAS 1128165-88-7 - Calbiochem

Overview

Key Specifications Table

CAS #Empirical Formula
1128165-88-7C₂₅H₃₆N₄O

Products

Catalog NumberPackaging Qty/Pack
324414-10MG Glass bottle 10 mg
Description
OverviewA cell-permeable, allosteric Dynamin inhibitor (IC50 = 6.9 µM and 14 µM for full length Dynamin I and Dynamin II GTPase activity, respectively, in vitro). 10 µM of this compound results in cytokinesis failure at the abscission stage in HeLa cultures, with 82% of cells that enter into mitosis becoming multinucleated, and with 97% resulting in cell death. However, it displays a much reduced effect in NIH3T3 cells at the same concentration. It elicits a dose-dependent reduction in cell growth against SMA-560, SJ-G2, SW480, MCF-7 and A2780 cultures, as being the most sensitive among a panel of other cancer cell lines (GI50 = 4.0–37 µM). It was further shown to be 6-fold more active (IC50 = 5.0 µM) than dynamin mediated receptor mediated endocytosis (RME) in U2OS cells, and 15-fold more active (IC50 = 1.3 µM) than Dynasore (Cat. No. 324410) in another Dynamin I GTPase activity assay.
Catalogue Number324414
Brand Family Calbiochem®
Synonyms2-Cyano-N-octyl-3-(1-(3-dimethylaminopropyl)-1H-indol-3-yl)-acrylamide
References
ReferencesChircop, M. et al. 2011. Mol. Cancer Ther. 10, 1553.
Hill, T.A., et al. 2009. J. Med. Chem. 52, 3762.
Product Information
CAS number1128165-88-7
FormYellow solid
Hill FormulaC₂₅H₃₆N₄O
Chemical formulaC₂₅H₃₆N₄O
Structure formula ImageStructure formula Image
Quality LevelMQ100
Biological Information
Purity≥99% by HPLC
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Global Trade Item Number
Catalog Number GTIN
324414-10MG 04055977197204