324414 Sigma-AldrichDynamin Inhibitor V, 34-2 - CAS 1128165-88-7 - Calbiochem
The Dynamin Inhibitor V, 34-2 controls the biological activity of Dynamin. This small molecule/inhibitor is primarily used for Membrane applications.
More>> The Dynamin Inhibitor V, 34-2 controls the biological activity of Dynamin. This small molecule/inhibitor is primarily used for Membrane applications. Less<<Synonyms: 2-Cyano-N-octyl-3-(1-(3-dimethylaminopropyl)-1H-indol-3-yl)-acrylamide
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Overview
Key Specifications Table
CAS # | Empirical Formula |
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1128165-88-7 | C₂₅H₃₆N₄O |
Products
Catalog Number | Packaging | Qty/Pack | |
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324414-10MG | Glass bottle | 10 mg |
Description | |
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Overview | A cell-permeable, allosteric Dynamin inhibitor (IC50 = 6.9 µM and 14 µM for full length Dynamin I and Dynamin II GTPase activity, respectively, in vitro). 10 µM of this compound results in cytokinesis failure at the abscission stage in HeLa cultures, with 82% of cells that enter into mitosis becoming multinucleated, and with 97% resulting in cell death. However, it displays a much reduced effect in NIH3T3 cells at the same concentration. It elicits a dose-dependent reduction in cell growth against SMA-560, SJ-G2, SW480, MCF-7 and A2780 cultures, as being the most sensitive among a panel of other cancer cell lines (GI50 = 4.0–37 µM). It was further shown to be 6-fold more active (IC50 = 5.0 µM) than dynamin mediated receptor mediated endocytosis (RME) in U2OS cells, and 15-fold more active (IC50 = 1.3 µM) than Dynasore (Cat. No. 324410) in another Dynamin I GTPase activity assay. |
Catalogue Number | 324414 |
Brand Family | Calbiochem® |
Synonyms | 2-Cyano-N-octyl-3-(1-(3-dimethylaminopropyl)-1H-indol-3-yl)-acrylamide |
References | |
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References | Chircop, M. et al. 2011. Mol. Cancer Ther. 10, 1553. Hill, T.A., et al. 2009. J. Med. Chem. 52, 3762. |
Product Information | |
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CAS number | 1128165-88-7 |
Form | Yellow solid |
Hill Formula | C₂₅H₃₆N₄O |
Chemical formula | C₂₅H₃₆N₄O |
Structure formula Image | |
Quality Level | MQ100 |
Biological Information | |
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Purity | ≥99% by HPLC |
Packaging Information | |
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Packaged under inert gas | Packaged under inert gas |
Global Trade Item Number | |
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Catalog Number | GTIN |
324414-10MG | 04055977197204 |