509230 Sigma-AldrichER Export Inhibitor II, FLI-06 - Calbiochem
A cell-permeable compound that reversibly blocks cellular glycosylation and surface expression of Notch, APP, Klotho by blocking events prior to cargo assembly at the ER exit sites.
More>> A cell-permeable compound that reversibly blocks cellular glycosylation and surface expression of Notch, APP, Klotho by blocking events prior to cargo assembly at the ER exit sites. Less<<ER Export Inhibitor II, FLI-06 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Synonyms: Cyclohexyl 2,7,7-trimethyl-4-(4-nitrophenyl)-5-oxo-1,4,5,6,7,8-hexahydroquinoline-3-carboxylate, Cyclohexyl 4-(4ʹ-nitrophenyl)-2,7,7-trimethyl-5-oxo-1,4,5,6,7,8-hexahydroquinoline-3-carboxylate, FLI06
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Overview
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Key Specifications Table
| Empirical Formula |
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| C₂₅H₃₀N₂O₅ |
Products
| Catalog Number | Packaging | Qty/Pack | |
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| 5.09230.0001 | Glass bottle | 10 mg |
| Description | |
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| Overview | A cell-permeable, non-toxic, dihydropyrimidine compound that prevents cellular glycosylation and surface expression of Notch, APP, Klotho (Effect. conc. = 10 µM in HEK293, HeLa, U2OS cultures) in a rapid and reversible manner by blocking events prior to cargo assembly at the ER exit sites (ERES) without affecting other post-ERES events targeted by BFA, GCA, Exo1, A5, Retro-2, U18666A, or Vacuolin-1 (Cat. nos. 203729, 345862, 341220, 444805, 554715, 662015, & 673000, respectively). Notch signaling is shown to be effectively inhibited by treatment with either FLI-06 or the γ-Secretase inhibitior DAPT (Cat. nos. 565770 & 565784) in both C2C12 cultures (10 µM FLI-06) in vitro and in zebrafish embryos (50 µM FLI-06) in vivo. |
| Catalogue Number | 509230 |
| Brand Family | Calbiochem® |
| Synonyms | Cyclohexyl 2,7,7-trimethyl-4-(4-nitrophenyl)-5-oxo-1,4,5,6,7,8-hexahydroquinoline-3-carboxylate, Cyclohexyl 4-(4ʹ-nitrophenyl)-2,7,7-trimethyl-5-oxo-1,4,5,6,7,8-hexahydroquinoline-3-carboxylate, FLI06 |
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| References | Kramer, A., et al. 2013. Nat. Chem. Biol. 9, 731. |
| Product Information | |
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| Form | Yellow powder |
| Hill Formula | C₂₅H₃₀N₂O₅ |
| Chemical formula | C₂₅H₃₀N₂O₅ |
| Reversible | Y |
| Quality Level | MQ100 |
| Applications |
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| Biological Information | |
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| Primary Target | ER |
| Purity | ≥95% by HPLC |
| Physicochemical Information | |
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| Cell permeable | Y |
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| Toxicological Information |
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| Safety Information according to GHS |
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| Safety Information |
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| Product Usage Statements |
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| Packaging Information | |
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| Packaged under inert gas | Packaged under inert gas |
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| Specifications |
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| Global Trade Item Number | |
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| Catalog Number | GTIN |
| 5.09230.0001 | 04055977241723 |
Documentation
ER Export Inhibitor II, FLI-06 - Calbiochem SDS
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References
| Reference overview |
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| Kramer, A., et al. 2013. Nat. Chem. Biol. 9, 731. |
| Data Sheet | ||||||||||||||||||||||||||
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Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.
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