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328006 ERK Inhibitor - CAS 1049738-54-6 - Calbiochem

The ERK Inhibitor, also referenced under CAS 1049738-54-6, controls the biological activity of ERK. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 3-(2-Aminoethyl)-5-((4-ethoxyphenyl)methylene)-2,4-thiazolidinedione, HCl

Primary Target: ERK
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Overview

Replacement Information

Key Specifications Table

CAS #Empirical Formula
1049738-54-6C₁₄H₁₆N₂O₃S • HCl

Products

Catalog NumberPackaging Qty/Pack
328006-5MG Plastic ampoule 5 mg
Description
OverviewA cell-permeable and reversible thiazolidinedione compound that displays anti-proliferative properties (IC50 ≤ 25 µM in HeLa, A549, and SUM-159 tumor cells). Preferentially binds to ERK2 with a KD of ~5 µM and prevents its interaction with protein substrates. Shown to block ERK-mediated phosphorylation of ribosomal S6 kinase-1 (RSK-1) and ternary complex factor Elk-1 in HeLa cells, while exhibiting little effect on ERK1/2 phosphorylation by MEK1/2.
Catalogue Number328006
Brand Family Calbiochem®
Synonyms3-(2-Aminoethyl)-5-((4-ethoxyphenyl)methylene)-2,4-thiazolidinedione, HCl
References
ReferencesHancock, C. N., et al. 2005. J. Med. Chem. 48, 4586.
Product Information
CAS number1049738-54-6
ATP CompetitiveN
FormLight yellow solid
Hill FormulaC₁₄H₁₆N₂O₃S • HCl
Chemical formulaC₁₄H₁₆N₂O₃S • HCl
Hygroscopic Hygroscopic
ReversibleY
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetERK
Primary Target IC<sub>50</sub>≤ 25 µM for anti-proliferative properties in HeLa, A549, and SUM-159 tumor cells; KD of ~5 µM for ERK2
Purity≥95% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalog Number GTIN
328006-5MG 04055977196351

Documentation

ERK Inhibitor - CAS 1049738-54-6 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

ERK Inhibitor - CAS 1049738-54-6 - Calbiochem Certificates of Analysis

TitleLot Number
328006

References

Reference overview
Hancock, C. N., et al. 2005. J. Med. Chem. 48, 4586.

Brochure

Title
MAPK Pathway Poster ( 750 KB )
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision08-April-2011 RFH
Synonyms3-(2-Aminoethyl)-5-((4-ethoxyphenyl)methylene)-2,4-thiazolidinedione, HCl
DescriptionA cell-permeable and reversible thiazolidinedione compound that displays anti-proliferative properties (IC50 ≤25 µM in HeLa, A549, and SUM-159 tumor cells). Preferentially binds to ERK2 with a KD of ~5 µM and prevents its interaction with protein substrates. Shown to block ERK-mediated phosphorylation of ribosomal S6 kinase-1 (RSK-1) and ternary complex factor Elk-1 in HeLa cells, while exhibiting little effect on ERK1/2 phosphorylation by MEK1/2.
FormLight yellow solid
Intert gas (Yes/No) Packaged under inert gas
CAS number1049738-54-6
Chemical formulaC₁₄H₁₆N₂O₃S • HCl
Structure formulaStructure formula
Purity≥95% by HPLC
SolubilityDMSO (10 mg/ml)
Storage Protect from light
+2°C to +8°C
Hygroscopic
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesHancock, C. N., et al. 2005. J. Med. Chem. 48, 4586.