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14-561M EphB3 Protein, active, 250 µg

Active, N-terminal His6-tagged recombinant human EphB3 residues 599-920, for use in Kinase Assays.

14-561M
250 µg  Also available in 10 μg size (cat#14-561) and in bulk (cat# 14-561-K).
Purchase on Sigma-Aldrich

Overview

Replacement Information
Description
Catalogue Number14-561M
Brand Family Upstate
Trade Name
  • Upstate
DescriptionEphB3 Protein, active, 250 µg
OverviewN-terminal His6-tagged recombinant human EphB3 residues 599-920
References
Product Information
Quality LevelMQ300
Applications
ApplicationActive, N-terminal His6-tagged recombinant human EphB3 residues 599-920, for use in Kinase Assays.
Key Applications
  • Kinase Assay
Biological Information
SourceExpressed by baculovirus in Sf21 insect cells
Specific ActivityFor Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
Entrez Gene Number
Entrez Gene SummaryEphrin receptors and their ligands, the ephrins, mediate numerous developmental processes, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family. The protein encoded by this gene is a receptor for ephrin-B family members.
Gene Symbol
  • EPHB3
  • TYRO6
  • ETK2
  • Hek2
  • Tyro6
  • EphB3
  • HEK2
Protein TargetEphB3
Purification MethodNi2+/NTA-agarose
Target Sub-FamilyTK
UniProt Number
UniProt SummaryFUNCTION: SwissProt: P54753 # Receptor for members of the ephrin-B family. Binds to ephrin-B1 and -B2.
SIZE: 998 amino acids; 110330 Da
SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
TISSUE SPECIFICITY: Ubiquitous.
SIMILARITY: SwissProt: P54753 ## Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily. & Contains 2 fibronectin type-III domains. & Contains 1 protein kinase domain. & Contains 1 SAM (sterile alpha motif) domain.
Molecular Weight40kDa
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality AssuranceRoutinely evaluated by phosphorylation of Poly (Glu4-Tyr) (4:1)
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions6 months at -70°C
Packaging Information
Material Size250 µg
Material PackageAlso available in 10 μg size (cat#14-561) and in bulk (cat# 14-561-K).
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalog Number GTIN
14-561M 04053252510014

Documentation

Related Products & Applications

Alternative Packsize

Catalog Number Description
14-561 EphB3 Protein, active, 10 µg

Product Families

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Millipore offers a large portfolio of Kinases, Phophatases, Substrates, Inhibitors, Kits, reagents & tools for Signaling research. See below for a list of these products, in multiple pack sizes.
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Categories

Life Science Research > Proteins and Enzymes > Purified Kinases
Life Science Research > Drug Discovery and Development > Kinase & Phosphatase Screening > Purified Kinases