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341291 Fas/FasL Antagonist, Kp7-6 - Calbiochem

The Fas/FasL Antagonist, Kp7-6 controls the biological activity of Fas/FasL. This small molecule/inhibitor is primarily used for Cancer applications.

Fas/FasL Antagonist, Kp7-6 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: H-YC*DEHFC*Y-OH, Cyclic [Cys-Cys disulfide], Kp7-6

Primary Target: Fas/FasL-mediated cellular apoptotic signals
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341291
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Overview

Replacement Information

Key Specifications Table

Empirical Formula
C₄₈H₅₆N₁₀O₁₅S₂

Products

Catalog NumberPackaging Qty/Pack
341291-25MG Plastic ampoule 25 mg
Description
OverviewAn exocyclic cystine-knot peptide that specifically antagonizes Fas/FasL-mediated cellular apoptotic signals (58% reduction of FasL-induced apoptosis in Jurkat cells at 1 mg/ml). Binds to FasL (Cat. Nos. PF033 and PF092) and Fas (CD95/APO-1) with comparable affinity (Kd = 11.2 & 13.2 µM, respectively), resulting in disabled receptor ensembles and altered signaling pathways. Shown to prevent Con A (Cat. No. 234567)-induced liver injury in a murine hepatitis model in vivo. Does not bind to TNF-α or TNFR.
Catalogue Number341291
Brand Family Calbiochem®
SynonymsH-YC*DEHFC*Y-OH, Cyclic [Cys-Cys disulfide], Kp7-6
References
ReferencesCarmona, E.M., et al. 2006. J. Immunol. 177, 459.
Hasegawa, A., et al. 2004. Proc. Natl. Acad. Sci. USA 101, 6599.
Product Information
ATP CompetitiveN
DeclarationSold under license of U.S. Patent 7,288,519.
FormWhite lyophilized powder
FormulationSupplied as a trifluoroacetate salt.
Hill FormulaC₄₈H₅₆N₁₀O₁₅S₂
Chemical formulaC₄₈H₅₆N₁₀O₁₅S₂
Hygroscopic Hygroscopic
ReversibleN
Quality LevelMQ100
Applications
Biological Information
Primary TargetFas/FasL-mediated cellular apoptotic signals
Primary Target IC<sub>50</sub>Kd = 11.2 & 13.2 µM for FasL and Fas (CD95/APO-1), respectively
Purity≥98% by HPLC
Physicochemical Information
Cell permeableN
Peptide SequenceH₂N-Tyr-Cys*-Asp-Glu-His-Phe-Cys*-Tyr-CO₂H, Cyclic [disulfide bond between Cys-Cys]
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalog Number GTIN
341291-25MG 04055977215618

Documentation

Fas/FasL Antagonist, Kp7-6 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

Fas/FasL Antagonist, Kp7-6 - Calbiochem Certificates of Analysis

TitleLot Number
341291

References

Reference overview
Carmona, E.M., et al. 2006. J. Immunol. 177, 459.
Hasegawa, A., et al. 2004. Proc. Natl. Acad. Sci. USA 101, 6599.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision15-January-2013 JSW
SynonymsH-YC*DEHFC*Y-OH, Cyclic [Cys-Cys disulfide], Kp7-6
DescriptionAn exocyclic cysteine-knot peptide that specifically antagonizes Fas/FasL-mediated cellular apoptotic signals (58% reduction of FasL-induced apoptosis in Jurkat cells at 1 mg/ml). Binds to FasL (Cat. Nos. PF033 and PF092) and Fas (CD95/APO-1) with comparable affinity (Kd = 11.2 & 13.2 µM, respectively), resulting in disabled receptor ensembles and altered signaling. Shown to prevent Con A (Cat. No. 234567)-induced liver injury in a murine hepatitis model in vivo. Does not bind to TNF-α or TNFR.
FormWhite lyophilized powder
FormulationSupplied as a trifluoroacetate salt.
Intert gas (Yes/No) Packaged under inert gas
Chemical formulaC₄₈H₅₆N₁₀O₁₅S₂
Peptide SequenceH₂N-Tyr-Cys*-Asp-Glu-His-Phe-Cys*-Tyr-CO₂H, Cyclic [disulfide bond between Cys-Cys]
Purity≥98% by HPLC
SolubilityDMSO (5 mg/ml)
Storage Protect from light
+2°C to +8°C
Hygroscopic
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesCarmona, E.M., et al. 2006. J. Immunol. 177, 459.
Hasegawa, A., et al. 2004. Proc. Natl. Acad. Sci. USA 101, 6599.