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343020 Flt-3 Inhibitor - CAS 301305-73-7 - Calbiochem

The Flt-3 Inhibitor, also referenced under CAS 301305-73-7, controls the biological activity of Flt-3. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Primary Target: Flt-3
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343020
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Overview

Replacement Information

Key Specifications Table

CAS #Empirical Formula
301305-73-7C₁₈H₂₀N₂O₄S

Products

Catalog NumberPackaging Qty/Pack
343020-5MG Plastic ampoule 5 mg
Description
OverviewA cell-permeable thienylcarboxamide compound that acts as a potent, ATP-competitive, and highly selective Flt-3 inhibitor (IC50 = 42 nM) with little effect against a panel of 22 other kinases (IC50 ≥3 µM). Shown to exhibit antiproliferative properties against the human acute myelogenous leukemia cell line MV4-11 (IC50 = 340 nM) expressing constitutively active Flt-3.
Catalogue Number343020
Brand Family Calbiochem®
References
ReferencesPatch, R.J., et al. 2006. Bioorg. Med. Chem. Lett. 16, 3282.
Product Information
CAS number301305-73-7
ATP CompetitiveY
FormWhite solid
Hill FormulaC₁₈H₂₀N₂O₄S
Chemical formulaC₁₈H₂₀N₂O₄S
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetFlt-3
Primary Target IC<sub>50</sub>42 nM against Flt-3
Purity≥98% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Irritant
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalog Number GTIN
343020-5MG 04055977195019

Documentation

Flt-3 Inhibitor - CAS 301305-73-7 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

Flt-3 Inhibitor - CAS 301305-73-7 - Calbiochem Certificates of Analysis

TitleLot Number
343020

References

Reference overview
Patch, R.J., et al. 2006. Bioorg. Med. Chem. Lett. 16, 3282.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision10-October-2007 JSW
DescriptionA cell-permeable thienylcarboxamide compound that acts as a potent, ATP-competitive, and highly selective Flt-3 inhibitor (IC50 = 42 nM) with little effect against a panel of 22 other kinases (IC50 ≥3 µM). Shown to exhibit antiproliferative properties against the human acute myelogenous leukemia cell line MV4-11 (IC50 = 340 nM) expressing constitutively active Flt-3.
FormWhite solid
Intert gas (Yes/No) Packaged under inert gas
CAS number301305-73-7
Chemical formulaC₁₈H₂₀N₂O₄S
Structure formulaStructure formula
Purity≥98% by HPLC
SolubilityDMSO (<4 mg/ml)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity Irritant
ReferencesPatch, R.J., et al. 2006. Bioorg. Med. Chem. Lett. 16, 3282.