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344845 Fumagillin, Aspergillus fumigatus - CAS 23110-15-8 - Calbiochem

Antiprotozoal agent and angiogenesis inhibitor.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Fumidil B, MetAP-2 Inhibitor I, MetAP2 Inhibitor I, Methionine Aminopeptidase 2 Inhibitor I

Primary Target: Methionine amino-peptidase 2
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344845
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Overview

Replacement Information

Key Specifications Table

CAS #Empirical Formula
23110-15-8C₂₆H₃₄O₇

Products

Catalog NumberPackaging Qty/Pack
344845-500UG Plastic ampoule 500 μg
Description
OverviewAntiprotozoal agent and angiogenesis inhibitor. Acts as an inhibitor of methionine amino-peptidase 2.
Catalogue Number344845
Brand Family Calbiochem®
SynonymsFumidil B, MetAP-2 Inhibitor I, MetAP2 Inhibitor I, Methionine Aminopeptidase 2 Inhibitor I
References
ReferencesZhang, P., et al. 2002. J. Biomed. Sci. 9, 34.
Stepien, H., et al. 1996. J. Endocrinol. 150, 99.
Abrams, J.S., et al. 1994. Cancer 74, 1164.
Jenkins, D.C., et al. 1993. Br. J. Cancer 68, 856.
Le Querrec, A., et al. 1993. Baillieres Clin. Hematol. 6, 711.
Molnar, K. 1993. Acta Vet. Hung. 41, 51.
Kusada, M., et al. 1991. Biochem. Biophys. Res. Commun. 174, 1070.
Brackett, J.M., et al. 1988. J. Agric. Food Chem. 36, 762.
Product Information
CAS number23110-15-8
ATP CompetitiveN
FormWhite to off-white powder
Hill FormulaC₂₆H₃₄O₇
Chemical formulaC₂₆H₃₄O₇
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetMethionine amino-peptidase 2
Purity≥90% by HPLC
Physicochemical Information
Cell permeableN
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
RTECSHE1750000
Safety Information
R PhraseR: 22

Harmful if swallowed.
S PhraseS: 36

Wear suitable protective clothing.
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Harmful
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalog Number GTIN
344845-500UG 04055977214857

Documentation

Fumagillin, Aspergillus fumigatus - CAS 23110-15-8 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

Fumagillin, Aspergillus fumigatus - CAS 23110-15-8 - Calbiochem Certificates of Analysis

TitleLot Number
344845

References

Reference overview
Zhang, P., et al. 2002. J. Biomed. Sci. 9, 34.
Stepien, H., et al. 1996. J. Endocrinol. 150, 99.
Abrams, J.S., et al. 1994. Cancer 74, 1164.
Jenkins, D.C., et al. 1993. Br. J. Cancer 68, 856.
Le Querrec, A., et al. 1993. Baillieres Clin. Hematol. 6, 711.
Molnar, K. 1993. Acta Vet. Hung. 41, 51.
Kusada, M., et al. 1991. Biochem. Biophys. Res. Commun. 174, 1070.
Brackett, J.M., et al. 1988. J. Agric. Food Chem. 36, 762.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision05-July-2017 JSW
SynonymsFumidil B, MetAP-2 Inhibitor I, MetAP2 Inhibitor I, Methionine Aminopeptidase 2 Inhibitor I
DescriptionAn inhibitor of angiogenesis. Has selective cytostatic effects against ras transformed cells (IC50 = 10 pM). Antiprotozoal agent active against sporozoan parasites in bees and myxozoan parasites in fish.
FormWhite to off-white powder
Intert gas (Yes/No) Packaged under inert gas
CAS number23110-15-8
RTECSHE1750000
Chemical formulaC₂₆H₃₄O₇
Structure formulaStructure formula
Purity≥90% by HPLC
SolubilityMethanol (5 mg/ml)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
Toxicity Harmful
Merck USA index14, 4286
ReferencesZhang, P., et al. 2002. J. Biomed. Sci. 9, 34.
Stepien, H., et al. 1996. J. Endocrinol. 150, 99.
Abrams, J.S., et al. 1994. Cancer 74, 1164.
Jenkins, D.C., et al. 1993. Br. J. Cancer 68, 856.
Le Querrec, A., et al. 1993. Baillieres Clin. Hematol. 6, 711.
Molnar, K. 1993. Acta Vet. Hung. 41, 51.
Kusada, M., et al. 1991. Biochem. Biophys. Res. Commun. 174, 1070.
Brackett, J.M., et al. 1988. J. Agric. Food Chem. 36, 762.