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538254 GN44028 - Calbiochem

A cell-potent hypoxia-induced HIF-1α transcriptional activity inhibitor. Antiproliferative, acts via impairing HIF-1α/HIF-1β heterodimer-induced transcriptional pathway.

GN44028 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: N -(2,3-Dihydrobenzo[b][1,4]dioxin-6-yl)-1,4-dihydroindeno[1,2-c]pyrazol-3-amine, HIF-1 Inhibitor II

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538254
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Overview

Replacement Information

Products

Catalog NumberPackaging Qty/Pack
5.38254.0001 Glass bottle 10 mg
Description
OverviewA cell-permeable indenopyrazole based compound that potently suppresses hypoxia-induced HIF-1α transcription (IC50 = 14 nM in HRE-Luc HeLa cells) and VEGF-expression. Shown to effectively induce growth arrest in several cancer cells (IC50 = 2.1, 3.7 & 1.8 µM for HCT116, HepG2 & HeLa cells), although with reduced efficiency in PC3 (IC50 = 25.4 µM). Does neither affect HIF-1α protein accumulation nor HIF-1α/HIF-1β heterodimer complex formation. Suggested to act via impairing HIF-1α/HIF-1β heterodimer-induced transcriptional pathway.

Please note that the molecular weight for this compound is batch-specific due to variable water content. Please refer to the vial label or the certificate of analysis for the batch-specific molecular weight. The molecular weight provided represents the baseline molecular weight without water.
Catalogue Number538254
Brand Family Calbiochem®
SynonymsN -(2,3-Dihydrobenzo[b][1,4]dioxin-6-yl)-1,4-dihydroindeno[1,2-c]pyrazol-3-amine, HIF-1 Inhibitor II
DescriptionGN44028
References
ReferencesMinegishi, H., et al. 2013. ACS Med. Chem. Lett. 4, 297.
Product Information
FormBrown solid
Hill FormulaC₁₈H₁₅N₃O₂
Chemical formulaC₁₈H₁₅N₃O₂
ReversibleY
Quality LevelMQ100
Applications
Biological Information
Primary TargetHIF-1α
Primary Target IC<sub>50</sub>14 nM in HRE-Luc HeLa cells
Secondary targetVEGF
Purity≥98% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalog Number GTIN
5.38254.0001 04054839119552

Documentation

GN44028 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

References

Reference overview
Minegishi, H., et al. 2013. ACS Med. Chem. Lett. 4, 297.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision23-September-2016 JSW
SynonymsN -(2,3-Dihydrobenzo[b][1,4]dioxin-6-yl)-1,4-dihydroindeno[1,2-c]pyrazol-3-amine, HIF-1 Inhibitor II
DescriptionA cell-permeable indenopyrazole based compound that potently suppresses hypoxia-induced HIF-1α transcription (IC50 = 14 nM in HRE-Luc HeLa cells) and VEGF-expression. Shown to effectively induce growth arrest in several cancer cells (IC50 = 2.1, 3.7 & 1.8 µM for HCT116, HepG2 & HeLa cells), although with reduced efficiency in PC3 (IC50 = 25.4 µM). Does neither affect HIF-1α protein accumulation nor HIF-1α/HIF-1β heterodimer complex formation. Suggested to act via impairing HIF-1α/HIF-1β heterodimer-induced transcriptional pathway.
FormBrown solid
Intert gas (Yes/No) Packaged under inert gas
Chemical formulaC₁₈H₁₅N₃O₂
Purity≥98% by HPLC
SolubilityDMSO (50 mg/ml)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesMinegishi, H., et al. 2013. ACS Med. Chem. Lett. 4, 297.