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371721 GPR40 Agonist II - CAS 1206629-08-4 - Calbiochem

The GPR40 Agonist II controls the biological activity of GPR40. This small molecule/inhibitor is primarily used for Biochemicals applications.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 3-(4-((2,6-Dichloropyridin-4-yl)ethynyl)phenyl)propanoic acid, FFA1 Agonist II, Free Fatty Acid Receptor 1 Agonist II

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371721
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Overview

Replacement Information

Key Specifications Table

CAS #Empirical Formula
1206629-08-4C₁₆H₁₁Cl₂NO₂

Products

Catalog NumberPackaging Qty/Pack
371721-10MG Glass bottle 10 mg
Description
OverviewA cell-permeable alkynedihydrocinnamic acid that acts as a potent GPR40/FFA1 agonist (EC50 = 40.7 nM in inducing Ca2+ mobilization in hFFA1-expressing 1321N1 cells) with >100-fold selectivity over GPR43/FFA2, GPR41/FFA3, and a panel of 56 other receptors, ion channels, and transporters. Reported to enhance 12 mM glucose-induced insulin secretion from rat INS-1E β-cells (by 34% at 10 µM) and exhibit good aqueous solubility (199 µM in PBS at pH 7.4), as well as chemical and metabolic stability.
Catalogue Number371721
Brand Family Calbiochem®
Synonyms3-(4-((2,6-Dichloropyridin-4-yl)ethynyl)phenyl)propanoic acid, FFA1 Agonist II, Free Fatty Acid Receptor 1 Agonist II
References
ReferencesChristiansen, E., et al. 2011, J. Med. Chem. 54, 6691.
Product Information
CAS number1206629-08-4
FormOff-white powder
Hill FormulaC₁₆H₁₁Cl₂NO₂
Chemical formulaC₁₆H₁₁Cl₂NO₂
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Purity≥98% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C>
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalog Number GTIN
371721-10MG 04055977213249

Documentation

GPR40 Agonist II - CAS 1206629-08-4 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

GPR40 Agonist II - CAS 1206629-08-4 - Calbiochem Certificates of Analysis

TitleLot Number
371721

References

Reference overview
Christiansen, E., et al. 2011, J. Med. Chem. 54, 6691.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision24-September-2012 JSW
Synonyms3-(4-((2,6-Dichloropyridin-4-yl)ethynyl)phenyl)propanoic acid, FFA1 Agonist II, Free Fatty Acid Receptor 1 Agonist II
DescriptionA cell-permeable alkynedihydrocinnamic acid that acts as a potent GPR40/FFA1 agonist (EC50 = 40.7 nM in inducing Ca2+ mobilization in hFFA1-expressing 1321N1 cells) with >100-fold selectivity over GPR43/FFA2, GPR41/FFA3, and a panel of 56 other receptors, ion channels, and transporters. Reported to enhance 12 mM glucose-induced insulin secretion from rat INS-1E β-cells (by 34% at 10 µM) and exhibit good aqueous solubility (199 µM in PBS at pH 7.4), as well as chemical (0.1% degradation after 12 days in PBS at 37 °C) and metabolic (3% metabolization by human liver S9 stability test) stability.
FormOff-white powder
Intert gas (Yes/No) Packaged under inert gas
CAS number1206629-08-4
Chemical formulaC₁₆H₁₁Cl₂NO₂
Structure formulaStructure formula
Purity≥98% by HPLC
SolubilityDMSO (100 mg/ml; clear, colorless solution)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C>
Toxicity Standard Handling
ReferencesChristiansen, E., et al. 2011, J. Med. Chem. 54, 6691.