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505767 GSK-3beta Inhibitor XXVII, CESI - CAS 372102-47-1 - Calbiochem

Overview

Key Specifications Table

CAS #Empirical Formula
372102-47-1C₁₉H₁₆ClNO₆S

Products

Catalog NumberPackaging Qty/Pack
5.05767.0001 Glass bottle 10 mg
Description
OverviewA cell-permeable, 3-hydroxychromone derived compound that acts as a selective and reversible inhibitor of GSK-3β (IC50 < 100 nM). Shown to increase phosphorylation at Ser9. Does not show any inhibitory effect on a panel of 15 other protein kinases, including AMPK and Akt. By blocking GSK-3β activity, it acts as a positive regulator of b-catenin signaling. Does not affect the viability or the growth rate of 3T3-L1 preadipocytes, however, it significantly reduces their differentiation into adipocytes (˜ 50 to 100 nM). Exerts anti-adipogenic activity by down-regulating C/EBPa and PPARg. Shown to reduce adipocyte size and diminish weight gain in diet-induced obese mice without affecting their daily food intake.
Catalogue Number505767
Brand Family Calbiochem®
Synonyms2-(3-chloro-4-hydroxyphenyl)-8-(1,1-dioxidoisothiazolidin-2-yl)-3-hydroxy-6-methyl-4H-chromen-4-one
References
ReferencesS. Lee et al. 2013, Biochemical Pharmacology 85, 965.
Product Information
CAS number372102-47-1
FormYellow solid
Hill FormulaC₁₉H₁₆ClNO₆S
Chemical formulaC₁₉H₁₆ClNO₆S
ReversibleY
Structure formula ImageStructure formula Image
Quality LevelMQ100
Biological Information
Primary TargetGSK3b
Purity≥96% by HPLC
Physicochemical Information
Cell permeableY
Storage and Shipping Information
Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity Standard Handling
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Global Trade Item Number
Catalog Number GTIN
5.05767.0001 04055977262971