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505296 GYKI 53655 Hydrochloride - CAS 143692-48-2 - Calbiochem

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: LY 300168, GYKI-53655 hydrochloride, AMPA Glutamate Receptor Antagonist, GYKI 53655 hydrochloride, 1-(4-Aminophenyl)-3-methylcarbamyl-4-methyl-3,4-dihydro-7,8-methylenedioxy-5H-2,3-benzodiazepine hydrochloride

Primary Target: AMPA
505296
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Overview

Replacement Information

Key Specifications Table

CAS #Empirical Formula
143692-48-2C₁₉H₂₀N₄O₃•HCl

Products

Catalog NumberPackaging Qty/Pack
5.05296.0001 Glass bottle 10 mg
Description
OverviewA potent negative allosteric modulator selective for AMPA glutamate receptors (IC50 = 6 and 5 µM for GluA1 and GluA4, respectively) over kainate receptors (IC50 = 63 and 32 µM for GluK3 and GluK2b/GluK3 receptors. Used as neuroprotectant and anticonvulsant, and a valuable tool for the study of AMPA receptor-mediated processes in vivo.
Catalogue Number505296
Brand Family Calbiochem®
SynonymsLY 300168, GYKI-53655 hydrochloride, AMPA Glutamate Receptor Antagonist, GYKI 53655 hydrochloride, 1-(4-Aminophenyl)-3-methylcarbamyl-4-methyl-3,4-dihydro-7,8-methylenedioxy-5H-2,3-benzodiazepine hydrochloride
References
ReferencesKromann, H. et al. 2002. J. Med. Chem. 45, 5745.
Nilsen, A., et al. 2007. J. Am. Chem. Soc. 129, 4902.
Lante, F., et al. 2011. J. Neurosci. 31, 3953.
Argilli, E., et al. 2008. J. Neurosci. 28, 9092.
Jackson, C., et al. 2011. J. Neurosci. 31, 7511.
Product Information
CAS number143692-48-2
FormOrange solid
Hill FormulaC₁₉H₂₀N₄O₃•HCl
Chemical formulaC₁₉H₂₀N₄O₃•HCl
Structure formula ImageStructure formula Image
Applications
Biological Information
Primary TargetAMPA
Purity≥98% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalog Number GTIN
5.05296.0001 04055977243659

Documentation

GYKI 53655 Hydrochloride - CAS 143692-48-2 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

References

Reference overview
Kromann, H. et al. 2002. J. Med. Chem. 45, 5745.
Nilsen, A., et al. 2007. J. Am. Chem. Soc. 129, 4902.
Lante, F., et al. 2011. J. Neurosci. 31, 3953.
Argilli, E., et al. 2008. J. Neurosci. 28, 9092.
Jackson, C., et al. 2011. J. Neurosci. 31, 7511.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision26-July-2013 JSW
SynonymsLY 300168, GYKI-53655 hydrochloride, AMPA Glutamate Receptor Antagonist, GYKI 53655 hydrochloride, 1-(4-Aminophenyl)-3-methylcarbamyl-4-methyl-3,4-dihydro-7,8-methylenedioxy-5H-2,3-benzodiazepine hydrochloride
DescriptionA potent negative allosteric modulator selective for AMPA glutamate receptors (IC50 = 6 and 5 µM for GluA1 and GluA4, respectively) over kainate receptors (IC50 = 63 and 32 µM for GluK3 and GluK2b/GluK3 receptors. Used as neuroprotectant and anticonvulsant, and a valuable tool for the study of AMPA receptor-mediated processes in vivo.
FormOrange solid
CAS number143692-48-2
Chemical formulaC₁₉H₂₀N₄O₃•HCl
Structure formulaStructure formula
Purity≥98% by HPLC
SolubilityH₂O (100 mM)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesKromann, H. et al. 2002. J. Med. Chem. 45, 5745.
Nilsen, A., et al. 2007. J. Am. Chem. Soc. 129, 4902.
Lante, F., et al. 2011. J. Neurosci. 31, 3953.
Argilli, E., et al. 2008. J. Neurosci. 28, 9092.
Jackson, C., et al. 2011. J. Neurosci. 31, 7511.