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345701 Gambogic Acid, Garcinia hanburyi - CAS 2752-65-0 - Calbiochem

A cell-permeable caspase activator and an apoptosis inducer that was originally isolated from gamboge resin for its antimicrobial properties.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Guttic Acid, β-Guttiferin

Primary Target: Caspase activator and an apoptosis inducer
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345701
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Overview

Replacement Information

Key Specifications Table

CAS #Empirical Formula
2752-65-0C₃₈H₄₄O₈

Products

Catalog NumberPackaging Qty/Pack
345701-25MG Alu drum 25 mg
Description
OverviewA cell-permeable caspase activator and an apoptosis inducer that was originally isolated from gamboge resin for its antimicrobial properties. Shown to inhibit the growth of HeLa and HEL cells minimal inhibitory concentrations (MIC = 12.5 µg/ml).
Catalogue Number345701
Brand Family Calbiochem®
SynonymsGuttic Acid, β-Guttiferin
References
ReferencesPrasad, S., et al. 2011. Cancer Prev. Res. 4, 1084.
Guo, Q.L., et al. 2004. Acta Pharmacol. Sin. 25, 769.
Asano, J., et al. 1996. Phytochemistry 41, 815.
Product Information
CAS number2752-65-0
ATP CompetitiveN
FormAmorphous orange solid
Hill FormulaC₃₈H₄₄O₈
Chemical formulaC₃₈H₄₄O₈
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetCaspase activator and an apoptosis inducer
Primary Target IC<sub>50</sub>MIC = 12.5 µg/ml in inhibiting the growth of HeLa and HEL cells
Purity≥95% by TLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
RTECSPB9268200
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Toxic & Carcinogenic / Teratogenic
Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalog Number GTIN
345701-25MG 04055977193787

Documentation

Gambogic Acid, Garcinia hanburyi - CAS 2752-65-0 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

Gambogic Acid, Garcinia hanburyi - CAS 2752-65-0 - Calbiochem Certificates of Analysis

TitleLot Number
345701

References

Reference overview
Prasad, S., et al. 2011. Cancer Prev. Res. 4, 1084.
Guo, Q.L., et al. 2004. Acta Pharmacol. Sin. 25, 769.
Asano, J., et al. 1996. Phytochemistry 41, 815.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision05-July-2017 JSW
SynonymsGuttic Acid, β-Guttiferin
DescriptionA cell-permeable, anti-microbial xanthone orignally isolated from the gamboge resin of Garcinia hanburyi. Acts as a caspase activator and apoptosis inducer. Shown to inhibit the growth of HeLa and HEL cells (MIC = 12.5 µg/ml). Reported to block telomerase activity in SMMC-7721 cells. Shown to induce tyrosine kinase phosphatase SHP-1 and suppress Stat3 activation.
FormAmorphous orange solid
Intert gas (Yes/No) Packaged under inert gas
CAS number2752-65-0
RTECSPB9268200
Chemical formulaC₃₈H₄₄O₈
Structure formulaStructure formula
Purity≥95% by TLC
SolubilityDMSO (10 mg/ml) or Ethanol
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Toxic & Carcinogenic / Teratogenic
Merck USA index14, 4361
ReferencesPrasad, S., et al. 2011. Cancer Prev. Res. 4, 1084.
Guo, Q.L., et al. 2004. Acta Pharmacol. Sin. 25, 769.
Asano, J., et al. 1996. Phytochemistry 41, 815.