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370625 Guanabenz Acetate - CAS 23256-50-0 - Calbiochem

A cell-permeable α2-adrenoceptor agonist that lowers protein misfolding in stressed cells and acts as a proteostatis regulator.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 1-(2,6-Dichlorobenzylideneamino)guanidine, Acetate, WY-8678

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Overview

Replacement Information

Key Specifications Table

CAS #Empirical Formula
23256-50-0C₈H₈Cl₂N₄ • C₂H₄O₂

Products

Catalog NumberPackaging Qty/Pack
370625-100MG Glass bottle 100 mg
Description
OverviewA cell-permeable α2-adrenoceptor agonist that lowers protein misfolding in stressed cells (EC50 ~ 400 nM in tunicamycin treated HeLa cells) and acts as a proteostatis regulator. Shown to selectively bind PPP1R15A/GADD34 and disrupt the PPP1R15A-PP1c complex; sustain eIF2α phosphorylation and increase chaperone availability by attenuating translation.
Catalogue Number370625
Brand Family Calbiochem®
Synonyms1-(2,6-Dichlorobenzylideneamino)guanidine, Acetate, WY-8678
References
ReferencesTsaytler, P., et al. 2011. Science 332, 91.
Erb, S., et al. 2000. Neuropsychopharmacology 23, 138,
Handley, S.L. and Mithani, S., 1984. Naunyn Schmiedebergs Arch. Pharmacol. 327, 1.
Product Information
CAS number23256-50-0
FormWhite powder
Hill FormulaC₈H₈Cl₂N₄ • C₂H₄O₂
Chemical formulaC₈H₈Cl₂N₄ • C₂H₄O₂
Hygroscopic Hygroscopic
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Purity≥99% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalog Number GTIN
370625-100MG 04055977191622

Documentation

Guanabenz Acetate - CAS 23256-50-0 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

Guanabenz Acetate - CAS 23256-50-0 - Calbiochem Certificates of Analysis

TitleLot Number
370625

References

Reference overview
Tsaytler, P., et al. 2011. Science 332, 91.
Erb, S., et al. 2000. Neuropsychopharmacology 23, 138,
Handley, S.L. and Mithani, S., 1984. Naunyn Schmiedebergs Arch. Pharmacol. 327, 1.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision24-August-2012 JSW
Synonyms1-(2,6-Dichlorobenzylideneamino)guanidine, Acetate, WY-8678
DescriptionA cell-permeable α2-adrenoceptor agonist that lowers protein misfolding in stressed cells (EC50 ~ 400 nM in tunicamycin treated HeLa cells) and acts as a proteostatis regulator. Shown to selectively bind PPP1R15A/GADD34 and disrupt the PPP1R15A-PP1c complex; sustain eIF2α phosphorylation and increase chaperone availability by attenuating translation.
FormWhite powder
Intert gas (Yes/No) Packaged under inert gas
CAS number23256-50-0
Chemical formulaC₈H₈Cl₂N₄ • C₂H₄O₂
Structure formulaStructure formula
Purity≥99% by HPLC
SolubilityH₂O (5 mg/ml)
Storage Protect from light
+2°C to +8°C
Hygroscopic
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity Standard Handling
ReferencesTsaytler, P., et al. 2011. Science 332, 91.
Erb, S., et al. 2000. Neuropsychopharmacology 23, 138,
Handley, S.L. and Mithani, S., 1984. Naunyn Schmiedebergs Arch. Pharmacol. 327, 1.