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203820 Guanosine 3ʹ,5ʹ-cyclic Monophosphate, 8-Bromo-, Sodium Salt - CAS 51116-01-9 - Calbiochem

Cell-permeable cGMP analog that is more resistant to phosphodiesterases than cGMP.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 8-Bromo-cGMP, Br-cGMP, Na

Primary Target: protein kinase G
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Overview

Replacement Information

Key Specifications Table

CAS #Empirical Formula
51116-01-9C₁₀H₁₀BrN₅O₇P · Na

Products

Catalog NumberPackaging Qty/Pack
203820-25MG Plastic ampoule 25 mg
Description
OverviewCell-permeable cGMP analog that is more resistant to phosphodiesterases than cGMP. Preferentially activates protein kinase G. Inhibits thrombin-stimulated arachidonic acid release in human platelets.
Catalogue Number203820
Brand Family Calbiochem®
Synonyms8-Bromo-cGMP, Br-cGMP, Na
References
ReferencesKwak, B.R., and Jongsma, H.J. 1996. Mol. Cell. Biochem. 157, 93.
Perreault, T., and DeMarte, J. 1993. Am. J. Physiol. 264, H302.
Ruth, P., et al. 1991. Eur. J. Biochem. 202, 1339.
Schwarzschild, M.A., and Zigmond, R.E. 1991. J. Neurochem. 56, 400.
Product Information
CAS number51116-01-9
ATP CompetitiveN
FormWhite solid
Hill FormulaC₁₀H₁₀BrN₅O₇P · Na
Chemical formulaC₁₀H₁₀BrN₅O₇P · Na
Hygroscopic Hygroscopic
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary Targetprotein kinase G
Purity≥98% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Protect from Moisture Protect from moisture
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Aqueous stock solutions are stable for up to 1 week at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalog Number GTIN
203820-25MG 04055977204032

Documentation

Guanosine 3ʹ,5ʹ-cyclic Monophosphate, 8-Bromo-, Sodium Salt - CAS 51116-01-9 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

Guanosine 3ʹ,5ʹ-cyclic Monophosphate, 8-Bromo-, Sodium Salt - CAS 51116-01-9 - Calbiochem Certificates of Analysis

TitleLot Number
203820

References

Reference overview
Kwak, B.R., and Jongsma, H.J. 1996. Mol. Cell. Biochem. 157, 93.
Perreault, T., and DeMarte, J. 1993. Am. J. Physiol. 264, H302.
Ruth, P., et al. 1991. Eur. J. Biochem. 202, 1339.
Schwarzschild, M.A., and Zigmond, R.E. 1991. J. Neurochem. 56, 400.

Citations

Title
  • Bing Zhu, Samuel Strada and Troy Stevens. (2005) Cyclic GMP-specific phosphodiesterase 5 regulates growth and apoptosis in pulmonary endothelial cells. American Journal of Physiology Lung Cellular and Molecular Physiology 289, L196-L206.
    		•
    Data Sheet

    Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

    Revision22-May-2008 RFH
    Synonyms8-Bromo-cGMP, Br-cGMP, Na
    DescriptionCell-permeable cGMP analog that is more resistant to phosphodiesterases than cGMP. Preferentially activates protein kinase G. Inhibits thrombin-stimulated arachidonic acid release in human platelets.
    FormWhite solid
    Intert gas (Yes/No) Packaged under inert gas
    CAS number51116-01-9
    Chemical formulaC₁₀H₁₀BrN₅O₇P · Na
    Structure formulaStructure formula
    Purity≥98% by HPLC
    SolubilityH₂O (200 mg/ml)
    Storage Protect from moisture
    -20°C
    Hygroscopic
    Do Not Freeze Ok to freeze
    Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Aqueous stock solutions are stable for up to 1 week at -20°C.
    Toxicity Standard Handling
    ReferencesKwak, B.R., and Jongsma, H.J. 1996. Mol. Cell. Biochem. 157, 93.
    Perreault, T., and DeMarte, J. 1993. Am. J. Physiol. 264, H302.
    Ruth, P., et al. 1991. Eur. J. Biochem. 202, 1339.
    Schwarzschild, M.A., and Zigmond, R.E. 1991. J. Neurochem. 56, 400.
    Citation
  • Bing Zhu, Samuel Strada and Troy Stevens. (2005) Cyclic GMP-specific phosphodiesterase 5 regulates growth and apoptosis in pulmonary endothelial cells. American Journal of Physiology Lung Cellular and Molecular Physiology 289, L196-L206.
    		•