500498 Sigma-AldrichHIF Inhibitor V - CAS 1373443-16-3 - Calbiochem
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Overview
| Replacement Information |
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Key Specifications Table
| CAS # | Empirical Formula |
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| 1373443-16-3 | C₃₂H₃₈N₂O₅ |
Products
| Catalog Number | Packaging | Qty/Pack | |
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| 5.00498.0001 | Glass bottle | 10 mg |
| Description | |
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| Overview | A cell-permeable phenoxyacrylamido compound that inhibits hypoxia-induced cellular HIF-1α accumulation in a manner similar to LW6 (Cat. No. 400083) by upregulating Hippel-Lindau tumor suppressor gene product pVHL, but with much higher potency (IC50 = 120 nM vs 2.44 µM, respectively, against hypoxia-induced HRE reporter activity in HCT116 cells). Shown to suppress HIF-1 target genes expression in HCT116 cultures and inhibit HUVEC tubule formation (effective conc. ≥2 µM) under hypoxia conditions. Please note that the molecular weight for this compound is batch-specific due to variable water content. Please refer to the vial label or the certificate of analysis for the batch-specific molecular weight. The molecular weight provided represents the baseline molecular weight without water. |
| Catalogue Number | 500498 |
| Brand Family | Calbiochem® |
| Synonyms | Hypoxia-Inducible Factor Inhibitor V, (E)-3-(3-(4-Adamantan-1-ylphenoxy)acrylamido)benzoic acid morpholinoethyl ester |
| References | |
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| References | Naik, R., et al. 2012. J. Med. Chem. 55, 10564. |
| Product Information | |
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| CAS number | 1373443-16-3 |
| Form | White powder |
| Hill Formula | C₃₂H₃₈N₂O₅ |
| Chemical formula | C₃₂H₃₈N₂O₅ |
| Structure formula Image | |
| Quality Level | MQ100 |
| Applications |
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| Biological Information | |
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| Purity | ≥99% by HPLC |
| Physicochemical Information | |
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| Cell permeable | Y |
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| Toxicological Information |
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| Safety Information according to GHS |
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| Safety Information |
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| Product Usage Statements |
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| Packaging Information | |
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| Packaged under inert gas | Packaged under inert gas |
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| Supplemental Information |
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| Specifications |
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| Global Trade Item Number | |
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| Catalog Number | GTIN |
| 5.00498.0001 | 04055977245622 |
Documentation
HIF Inhibitor V - CAS 1373443-16-3 - Calbiochem SDS
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References
| Reference overview |
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| Naik, R., et al. 2012. J. Med. Chem. 55, 10564. |
| Data Sheet | ||||||||||||||||||||||||||||||
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Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.
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