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373402 Hedgehog Antagonist VIII - CAS 330796-24-2 - Calbiochem

The Hedgehog Antagonist VIII, also referenced under CAS 330796-24-2, controls the biological activity of Hedgehog. This small molecule/inhibitor is primarily used for Cell Signaling applications.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 1-(4-Chloro-3-(trifluoromethyl)phenyl)-3-((3-(4-fluorophenyl)-3,4-dihydro-4-oxo-2-quinazolinyl)methyl)-urea, Hh Signaling Antagonist VIII

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Overview

Replacement Information

Key Specifications Table

CAS #Empirical Formula
330796-24-2C₂₃H₁₅ClF₄N₄O₂

Products

Catalog NumberPackaging Qty/Pack
373402-5MG Plastic ampoule 5 mg
Description
OverviewA cell-permeable quinazolinyl-urea compound that is shown to potently inhibit OCT-Shh-stimulated Gli transcription activity in a 10t1/2(s12) cell-based Luciferase reporter assay (IC50 = 70 nM).
Catalogue Number373402
Brand Family Calbiochem®
Synonyms1-(4-Chloro-3-(trifluoromethyl)phenyl)-3-((3-(4-fluorophenyl)-3,4-dihydro-4-oxo-2-quinazolinyl)methyl)-urea, Hh Signaling Antagonist VIII
References
ReferencesBrunton, A.A., et al. 2008. J. Med. Chem. 51, 1108.
Product Information
CAS number330796-24-2
FormClear slightly yellow solid
Hill FormulaC₂₃H₁₅ClF₄N₄O₂
Chemical formulaC₂₃H₁₅ClF₄N₄O₂
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Purity≥95% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C0. Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalog Number GTIN
373402-5MG 04055977191127

Documentation

Hedgehog Antagonist VIII - CAS 330796-24-2 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

Hedgehog Antagonist VIII - CAS 330796-24-2 - Calbiochem Certificates of Analysis

TitleLot Number
373402

References

Reference overview
Brunton, A.A., et al. 2008. J. Med. Chem. 51, 1108.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision23-December-2009 RFH
Synonyms1-(4-Chloro-3-(trifluoromethyl)phenyl)-3-((3-(4-fluorophenyl)-3,4-dihydro-4-oxo-2-quinazolinyl)methyl)-urea, Hh Signaling Antagonist VIII
DescriptionA cell-permeable quinazolinyl-urea compound that is shown to potently inhibit OCT-Shh-stimulated Gli transcription activity in a 10t1/2(s12) cell-based Luciferase reporter assay (IC50 = 70 nM).
FormClear slightly yellow solid
Intert gas (Yes/No) Packaged under inert gas
CAS number330796-24-2
Chemical formulaC₂₃H₁₅ClF₄N₄O₂
Structure formulaStructure formula
Purity≥95% by HPLC
SolubilityDMSO (100 mg/ml)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C0. Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesBrunton, A.A., et al. 2008. J. Med. Chem. 51, 1108.