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373277 Hh Signaling Antagonist XI, MRT-14 - Calbiochem

The Hh Signaling Antagonist XI, MRT-14 controls the biological activity of Hh pathway. This small molecule/inhibitor is primarily used for Cell Signaling applications.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: N-(3-Benzamidophenylcarbamoyl)-3,4,5-trimethoxybenzamide, Smo Antagonist VIII

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Overview

Replacement Information

Key Specifications Table

Empirical Formula
C₂₄H₂₃N₃O₆
Description
OverviewA cell-permeable acylurea compound that acts as an antagonistic Smo ligand (IC50 = 120 nM against 5 nM Bodipy-cyclopamine binding to murine Smo-transfected HEK293 cells) and is more effective than Cyclopamine (Cat. No. 239803) in inhibiting ShhN-induced Gli transcription in Shh-light 2 cell assays (IC50 = 0.16 and 0.3 µM, respectively) and in blocking 0.1 µM SAG- (Cat. Nos. 566660 & 566661) stimulated differentiation of C3H10T1/2 murine mesenchymal stem cells into osteoblasts (IC50 = 0.13 and 0.62 µM, respectively).
Catalogue Number373277
Brand Family Calbiochem®
SynonymsN-(3-Benzamidophenylcarbamoyl)-3,4,5-trimethoxybenzamide, Smo Antagonist VIII
References
ReferencesManetti, F., et al. 2010. Mol. Pharmacol. 78, 658.
Product Information
FormWhite powder
Hill FormulaC₂₄H₂₃N₃O₆
Chemical formulaC₂₄H₂₃N₃O₆
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Purity≥98% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalog Number GTIN
373277 0

Documentation

Hh Signaling Antagonist XI, MRT-14 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

Hh Signaling Antagonist XI, MRT-14 - Calbiochem Certificates of Analysis

TitleLot Number
373277

References

Reference overview
Manetti, F., et al. 2010. Mol. Pharmacol. 78, 658.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision30-October-2012 JSW
SynonymsN-(3-Benzamidophenylcarbamoyl)-3,4,5-trimethoxybenzamide, Smo Antagonist VIII
DescriptionA cell-permeable acylurea compound that acts as an antagonistic Smo ligand (IC50 = 120 nM against 5 nM Bodipy-cyclopamine binding to murine Smo-transfected HEK293 cells) and is more effective than Cyclopamine (Cat. No. 239803) in inhibiting ShhN-induced Gli transcription in Shh-light 2 cell assays (IC50 = 0.16 and 0.3 µM, respectively) and in blocking 0.1 µM SAG- (Cat. Nos. 566660 and 566661) stimulated differentiation of C3H10T1/2 murine mesenchymal stem cells into osteoblasts (IC50 = 0.13 and 0.62 µM, respectively).
FormWhite powder
Intert gas (Yes/No) Packaged under inert gas
Chemical formulaC₂₄H₂₃N₃O₆
Structure formulaStructure formula
Purity≥98% by HPLC
SolubilityDMSO (100 mg/ml)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity Standard Handling
ReferencesManetti, F., et al. 2010. Mol. Pharmacol. 78, 658.