382149 Sigma-AldrichHistone Deacetylase Inhibitor III
The Histone Deacetylase Inhibitor III, also referenced under CAS 251456-60-7, controls the biological activity of Histone Deacetylase. This small molecule/inhibitor is primarily used for Cell Structure applications.
More>> The Histone Deacetylase Inhibitor III, also referenced under CAS 251456-60-7, controls the biological activity of Histone Deacetylase. This small molecule/inhibitor is primarily used for Cell Structure applications. Less<<Histone Deacetylase Inhibitor III MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Synonyms: M344, 4-Dimethylamino-N-(6-hydroxycarbamoylhexyl)benzamide, N-Hydroxy-7-(4-dimethylaminobenzoyl)aminoheptanamide
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Overview
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Key Specifications Table
| CAS # | Empirical Formula |
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| 251456-60-7 | C₁₆H₂₅N₃O₃ |
Products
| Catalog Number | Packaging | Qty/Pack | |
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| 382149-1MG | Plastic ampoule | 1 mg |
| Description | |
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| Overview | A cell-permeable amide analog of Trichostatin A (Cat. No. 647925) that potently inhibits histone deacetylases (IC50 = 40 nM for rat liver HDAC and IC50 = 100 nM for maize HD). Induces differentiation and inhibits proliferation (~2 µM) of murine erythroleukemia cells. |
| Catalogue Number | 382149 |
| Brand Family | Calbiochem® |
| Synonyms | M344, 4-Dimethylamino-N-(6-hydroxycarbamoylhexyl)benzamide, N-Hydroxy-7-(4-dimethylaminobenzoyl)aminoheptanamide |
| References | |
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| References | Ramiszewski, S.W., et al. 2002. J. Med. Chem. 45, 753. Jung, M., et al. 1999. J. Med. Chem. 42, 4669. |
| Product Information | |
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| CAS number | 251456-60-7 |
| ATP Competitive | N |
| Form | White solid |
| Hill Formula | C₁₆H₂₅N₃O₃ |
| Chemical formula | C₁₆H₂₅N₃O₃ |
| Reversible | N |
| Structure formula Image | |
| Quality Level | MQ100 |
| Applications |
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| Biological Information | |
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| Primary Target | Rat liver HDAC |
| Primary Target IC<sub>50</sub> | 40 nM for rat liver HDAC |
| Purity | ≥98% by HPLC |
| Physicochemical Information | |
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| Cell permeable | Y |
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| Product Usage Statements |
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| Packaging Information | |
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| Packaged under inert gas | Packaged under inert gas |
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| Specifications |
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| Global Trade Item Number | |
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| Catalog Number | GTIN |
| 382149-1MG | 04055977213164 |
Documentation
Histone Deacetylase Inhibitor III SDS
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Histone Deacetylase Inhibitor III Certificates of Analysis
| Title | Lot Number |
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| 382149 |
References
| Reference overview |
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| Ramiszewski, S.W., et al. 2002. J. Med. Chem. 45, 753. Jung, M., et al. 1999. J. Med. Chem. 42, 4669. |