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384620 Honokiol - CAS 35354-74-6 - Calbiochem

A biphenyl neolignan and an active principle of Magnolia extract that displays anti-angiogenic, anti-tumor and anxiolytic properties.

Honokiol - CAS 35354-74-6 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 5,3ʹ-Diallyl-2,4ʹ-dihydroxydiphenyl, VEGFR Tyrosine Kinase Inhibitor XIX, VEGFR2 Kinase Inhibitor XV

Primary Target: Anti-angiogenic, anti-tumor and anxiolytic properties
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384620
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Overview

Replacement Information

Key Specifications Table

CAS #Empirical Formula
35354-74-6C₁₈H₁₈O₂

Products

Catalog NumberPackaging Qty/Pack
384620-10MG Plastic ampoule 10 mg
Description
OverviewA biphenyl neolignan and an active principle of Magnolia extract that displays anti-angiogenic, anti-tumor and anxiolytic properties. Shown to induce apoptosis and preferentially inhibit the growth of primary human endothelial cells over fibroblasts by blocking VEGFR2 autophosphorylation and subsequent rac activation. Also blocks the in vivo growth of SVR angiosarcoma in nude mice.
Catalogue Number384620
Brand Family Calbiochem®
Synonyms5,3ʹ-Diallyl-2,4ʹ-dihydroxydiphenyl, VEGFR Tyrosine Kinase Inhibitor XIX, VEGFR2 Kinase Inhibitor XV
References
ReferencesBai, X., et al. 2003. J. Biol. Chem. 278, 35501.
Yang, S.E., et al. 2002. Biochem. Pharmacol. 63, 1641.
Son, H.J., et al. 2000. Planta Med. 66, 469.
Maruyama, Y., et al. 1998. J. Nat. Prod. 61, 135.
Product Information
CAS number35354-74-6
ATP CompetitiveN
FormWhite solid
Hill FormulaC₁₈H₁₈O₂
Chemical formulaC₁₈H₁₈O₂
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetAnti-angiogenic, anti-tumor and anxiolytic properties
Purity≥98% by HPLC
Physicochemical Information
Cell permeableN
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalog Number GTIN
384620-10MG 04055977190267

Documentation

Honokiol - CAS 35354-74-6 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

Honokiol - CAS 35354-74-6 - Calbiochem Certificates of Analysis

TitleLot Number
384620

References

Reference overview
Bai, X., et al. 2003. J. Biol. Chem. 278, 35501.
Yang, S.E., et al. 2002. Biochem. Pharmacol. 63, 1641.
Son, H.J., et al. 2000. Planta Med. 66, 469.
Maruyama, Y., et al. 1998. J. Nat. Prod. 61, 135.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision12-May-2008 RFH
Synonyms5,3ʹ-Diallyl-2,4ʹ-dihydroxydiphenyl, VEGFR Tyrosine Kinase Inhibitor XIX, VEGFR2 Kinase Inhibitor XV
DescriptionThe active principle of Magnolia extracts that exhibits anti-angiogenic, anti-tumor, anxiolytic, and chemoprotective properties. Shown to induce apoptosis and preferentially inhibit the growth of primary human endothelial cells over fibroblasts by blocking vascular endothelial growth factor receptor 2 (VEGFR2) autophosphorylation and subsequent rac activation. Also shown to block the growth of SVR angiosarcoma in nude mice.
FormWhite solid
Intert gas (Yes/No) Packaged under inert gas
CAS number35354-74-6
Chemical formulaC₁₈H₁₈O₂
Structure formulaStructure formula
Purity≥98% by HPLC
SolubilityDMSO (10 mg/ml) or Ethanol
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
Merck USA index14, 4742
ReferencesBai, X., et al. 2003. J. Biol. Chem. 278, 35501.
Yang, S.E., et al. 2002. Biochem. Pharmacol. 63, 1641.
Son, H.J., et al. 2000. Planta Med. 66, 469.
Maruyama, Y., et al. 1998. J. Nat. Prod. 61, 135.